Studies on Protective Coatings. I. The Synthesis and Properties of the Acid Soluble Cellulose Derivatives
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概要
- 論文の詳細を見る
A new type of acid soluble cellulose derivatives, in particular cellulose acetate N, Ndibutylaminohydroxypropyl ether (CABP), have been prepared by the reaction of 1-dialkylamino-2,3-epoxypropanes with the hydroxyl groups in partially hydrolyzed cellulose acetate. The CABP, besides being soluble in a number of common organic solvents, is also soluble in buffer solutions below pH 5.0 but not in neutral aqueous solutions. The compound, therefore, has been found a use in the film coating of tablets which are disintegrated in gastric juice. Water vapor permeability, tensile strength and percent elongation of the free film were tested in comparison with that of cellulose acetate phthalate. The practical coatings on tablets and the disintegration testings were carried out. These results, especially good film forming property, ease of handling and good stability of the film indicated that the CABP was practically useful as a tablet coating agent.
- 公益社団法人日本薬学会の論文
- 1968-10-25
著者
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野口 泰男
Research And Development Division Takeda Chemical Industries Ltd.
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野村 容朗
Research And Development Division Eisai Company Ltd.
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Nomura Hiroaki
Research And Development Division Eisai Company Ltd.
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平野 英幸
Research And Development Division Takeda Chemical Industries Ltd.
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宮田 勝昭
Research and Development Division, Takeda Chemical Industries, Ltd.
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宮田 勝昭
Central Research Division Takeda Chemical Industries Ltd.
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