Studies on L-Ascorbic Acid Derivatives. III. Bis (L-ascorbic acid-3,3') phosphate and L-Ascorbic Acid 2-Phosphate
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概要
- 論文の詳細を見る
Phosphorylation of 5,6-isopropylidene-L-ascorbic acid (I) in acetone with phosphoryl chloride gave, in addition to L-ascorbic acid 3-phosphate (II) and 3-pyrophosphate (III), the following two derivatives, i.e., bis (L-ascorbic acid-3,3') phosphate (IV) and L-ascorbic acid 2-phosphate (V). The structure of these phosphates was determined on the basis of elemental analysis, potentiometric titration, NMR-analysis, supplemented by studies of the hydrolysis. IV was hydrolyzed by acid and alkali most readily among the four isomers. By being passed through a column of Dowex-1-chloride with 1N hydrochloric acid, this compound quantitatively afforded equimolar amount of II and L-ascorbic acid. On the other hand, during the hydrolysis of V in 0.5N hydrochloric acid at 100°, the phosphoryl migration to II was ob served. On the alkali treatment, V was shown to be stable and no migration was detected.
- 公益社団法人日本薬学会の論文
- 1969-02-25
著者
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石黒 敏弘
Central Research Division, Takeda Chemical Industries, Ltd.
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森本 至郎
Central Research Laboratories Takeda Chemical Industries Ltd.
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野村 容朗
Research and Development Division, Eisai Company, Ltd.,
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野村 容朗
Research And Development Division Eisai Company Ltd.
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Nomura Hiroaki
Research And Development Division Eisai Company Ltd.
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森本 至郎
Research and Development Division, Takeda Chemical Industries, Ltd.
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石黒 敏弘
Research and Development Division, Takeda Chemical Industries, Ltd.
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石黒 敏弘
Central Research Division Takeda Chemical Industries Ltd.
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