Chemical Modification of Ansamitocins. I. Synthesis and Properties of 4,5-Deoxymaytansinoids
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概要
- 論文の詳細を見る
4,5-Deoxymaytansinoids, e.g., 4,5-deoxyansamitocin P-3 (VI) and 4,5-deoxymaytansine (VII), were synthesized a) by conversion of maytansinol into 4,5-deoxymaytansinol (V), followed by acylation using active esters of appropriate carboxylic acids, and b) by direct deoxygenation of the parent maytansinoids. Chromatographic and spectral analyses proved that conformational isomerism exists among these 4,5-deoxymaytansinoids. Compounds VI and VII showed biological activities characteristic of maytansine ; thus, the epoxide function in maytansinoids is not essential for their biological properties.
- 公益社団法人日本薬学会の論文
- 1984-06-25
著者
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橋本 直人
Central Research Division Takeda Chemical Industries Ltd.
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野村 容朗
Research and Development Division, Eisai Company, Ltd.,
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河合 昭悦
Central Research Division, Takeda Chemical Industries, Ltd.
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秋元 浩
Central Research Division, Takeda Chemical Industries, Ltd.
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野村 容明
Central Research Division, Takeda Chemical Industries, Ltd.
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野村 容朗
Research And Development Division Eisai Company Ltd.
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Nomura Hiroaki
Research And Development Division Eisai Company Ltd.
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秋元 浩
武田薬品工業(株)
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秋元 浩
武田薬品工業
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秋元 浩
武田薬品工業(株)化学研究所
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河合 昭悦
Central Research Division Takeda Chemical Industries Ltd.
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