Studies on Fluorinated Pyrimidines. II. Synthesis and Antitumor Activity of 5-Fluoro-6-substituted-5,6-dihydrouracil-5-carboxylic Acid Derivatives
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概要
- 論文の詳細を見る
Various derivatives of 5-fluoro-5,6-dihydrouracil with an alkoxycarbonyl, substituted carbamoyl, or cyano group at C-5,and one of a variety of substituents, i.e., alkoxy, substituted mercapto, substituted amino, acyl amino, and alkylidene- and arylideneaminooxy at C-6,have been synthesized as a class of potential pro-drugs of autitumor agents, 5-fluorouracil (5-FU) and 1-(2-tetrahydrofuryl)-5-fluorouracil (Ftorafur). Antitumor activity of these compounds against leukemia P388 or L1210 in mice and antifungal activity against Botrytis cinerea are described.
- 公益社団法人日本薬学会の論文
- 1982-03-25
著者
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笠原 俊彦
Central Research Division Takeda Chemical Industries Ltd.
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橋本 直人
Central Research Division Takeda Chemical Industries Ltd.
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宮下 修
Central Research Division, Takeda Chemical Industries, Ltd.
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松村 興一
Central Research Division, Takeda Chemical Industries, Ltd.
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島津 浩
Central Research Division, Takeda Chemical Industries, Ltd.
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島津 浩
Pharmaceutical Research Division Pharmaceutical Research Laboratories Iii Takeda Chemical Industires
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宮下 修
Central Research Division Takeda Chemical Industries Ltd.
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松村 興一
Central Research Division Takeda Chemical Industries Ltd.
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