Studies of Nitriles. IX. Reactions of 2-Acetylamino-3,3-dichloroacrylic Amide and-N-acylamide with Aliphatic Amines. (2). Syntheses of Some α, α-Diamino Acid Derivatives
スポンサーリンク
概要
- 論文の詳細を見る
Reaction of 2-acetylamino-3,3-dichloroacrylic-N-acetylamide (1) with aliphatic primary amines gave 2-acetylamino-2-(substituted amino)-3,3-dichloropropionamides (3) as major products, which differs distinctly from the results of reaction of 1 with aliphatic secondary amines which leads to oxazole derivatives 2. The 3 compounds were also prepared by addition of aliphatic primary and secondary amines to 2-acetylamino-3,3-dichloroacrylamide (6). Small amounts of 2-methyl-5-(substituted amino) oxazole-4-carboxamides (5) were obtained also. The mechanisms of these reactions are discussed.
- 公益社団法人日本薬学会の論文
- 1976-05-25
著者
-
橋本 直人
Central Research Division Takeda Chemical Industries Ltd.
-
宮下 修
Central Research Division, Takeda Chemical Industries, Ltd.
-
橋本 直人
Chemistry Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
-
松村 興一
Central Research Division, Takeda Chemical Industries, Ltd.
-
松村 興一
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
-
島津 浩
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
-
宮下 修
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
-
島津 浩
Pharmaceutical Research Division Pharmaceutical Research Laboratories Iii Takeda Chemical Industires
-
宮下 修
Central Research Division Takeda Chemical Industries Ltd.
-
松村 興一
Central Research Division Takeda Chemical Industries Ltd.
関連論文
- Synthetic Studies on Condensed-Azole Derivatives. III. Synthesis and Anti-asthmatic Activities of C-Substituted Alkyl Side Chain Derivatives of ω-Sulfamoylalkylthioimidazo[1,2-b]pyridazines and Related Compounds
- Synthesis and Enzymatic Activity of Adenosine 3', 5'-Cyclic Phosphate Analogs
- Synthesis and Coronary Vasodilating Activity of 2-Substituted Adenosines
- Chemical Modification of Ansamitocins. III. Synthesis and Biological Effects of 3-Acyl Esters of Maytansinol
- Chemical Modification of Ansamitocins. II. Synthesis of 3-Epimaytansionoids via 3-Maytansinones
- Chemical Modification of Ansamitocins. I. Synthesis and Properties of 4,5-Deoxymaytansinoids
- Studies on Fluorinated Pyrimidines. IV. Stereochemistry of 6-Alkoxy-5-fluoro-5,6-dihydrouracils and 5-Alkoxycarbonyl-5-fluoro-6-substituted-5,6-dihydrouracils
- Studies on Fluorinated Pyrimidines. III. Synthesis of 1-Acyl- and 1,3-Diacyl-5-alkoxycarbonyl-5-fluoro-6-substituted-5,6-dihydrouracils
- Studies on Fluorinated Pyrimidines. II. Synthesis and Antitumor Activity of 5-Fluoro-6-substituted-5,6-dihydrouracil-5-carboxylic Acid Derivatives
- Studies on Fluorinated Pyrimidines. I. A New Method of Synthesizing 5-Fluorouracil and Its Derivatives
- Studies of Nitriles. XI. Preparation and Chemistry of Schiff Bases of ADAN, 2-Amino-3,3-dichloroacrylonitrile. A highly Effective Conversion into 2-Substituted-4 (5)-chloroimidazole-5 (4)-carbaldehydes
- Studies of Nitriles. X. Synthesis and Reactions of 2-Acylamino-3,3-bis-(substituted mercapto) acrylonitriles and Their Derivatives. A New Synthesis of 2-Substituted-5-(substituted mercapto) oxazole-4-carbonitriles and Their Derivatives
- Studies of Nitriles. IX. Reactions of 2-Acetylamino-3,3-dichloroacrylic Amide and-N-acylamide with Aliphatic Amines. (2). Syntheses of Some α, α-Diamino Acid Derivatives
- Studies of Nitriles. VIII. Reactions of N-Acyl Derivatives of 2-Amino-3,3-dichloroacrylonitrile (ADAN) with Amines. (1). A New Synthesis of 2-Substituted-5-(substituted amino) oxazole-4-carbonitriles and-4-N-acylcarboxamides
- Studies of Nitriles. VII. Synthesis and Properties of 2-Amino-3,3-dichloroacrylonitrile (ADAN)
- Studies on Fluorinated Pyrimidines. V. Preparation of optically Active (+)-and (-)-t-6-Butoxy-r-5-ethoxycarbonyl-5-fluoro-5,6-dihydrouracils
- Syntheses of conformationally Rigid Catecholamine Derivatives
- Fused Pyrimidines. I. A One-step Synthesis of 3-Aminoisothiazolo [3,4-d]-pyrimidines from 6-Aminouracils and Vilsmeier Reagents
- A New Reaction of Nucleotides with Cyanoacetylene