Fused Pyrimidines. I. A One-step Synthesis of 3-Aminoisothiazolo [3,4-d]-pyrimidines from 6-Aminouracils and Vilsmeier Reagents
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概要
- 論文の詳細を見る
Reaction of 6-amino-1,3-diethyluracil (Ib) with dimethylformamide-thionyl chloride afforded 5,7-diethyl-3-dimethylaminoisothiazolo [3,4-d] pyrimidin-4,6 (5H, 7H)-dione (IVb) and three minor products (VIb, VIIb, VIIIb). Similar reactions of five 6-aminouracils or 6-amino-1-benzyl-cytosine (XV) with N-formyl-sec-amine-thionyl chloride afforded corresponding 3-aminoisothiazolo [3,4-d] pyrimidine derivatives (IVa-i or XVI). When 6-amino-1,3-diethyl-2-thiouracil (Ij) was allowed to react similarly, IVb was obtained as a major product and the yield of the expected 5,7-diethyl-3-dimethylaminoisothiazolo-[3,4-d] pyrimidin-4 (5H)-one-6 (7H)-thione (IVj) was very low.
- 公益社団法人日本薬学会の論文
- 1976-05-25
著者
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古川 純康
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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宮下 修
Central Research Division, Takeda Chemical Industries, Ltd.
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宮下 修
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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宮下 修
Central Research Division Takeda Chemical Industries Ltd.
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古川 純康
Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.
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島 俊介
Chemical Research Laboratories, Central Research Division Takeda Chemical Industries, Ltd.
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