Kondensierte Pyrimidine. III. Synthese von Isoxazolo [3,4-d] pyrimidinen
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概要
- 論文の詳細を見る
Die Umsetzung von 4-Hydroxyamino-uracilen (2) mit Saureanhydriden sowie Orthocarbonsaureestern in Gegenwart von Basen ergibt in guter Ausbeute Isoxazolo [3,4-d]-pyrimidin-4,6 (5H, 7H)-dione (3). Das intermediar gebildete 5-Acyl-4-acyloxyaminouracil (8) wurde isoliert und in 3 ubergefuhrt. Bei der Umsetzung von 4-Hydroxyamino-1,3-dimethyl-uracil (2b) mit Chlorameisensaureester in Gegenwart von Pyridin entsteht Pyrido [1', 2' : 2,3] pyrazolo [5,4-d] pyrimidin (10), deren Konstitution an Hand spektroskopischer Methoden aufgeklart wird.
- 社団法人日本薬学会の論文
- 1977-11-25
著者
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丸本 龍二
Central Research Laboratories Takeda Chemical Industries Ltd.
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丸本 龍二
Medicinal Research Laboratories, Takeda Chemical Industries, Ltd.
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古川 純康
Medicinal Research Laboratories, Takeda Chemical Industries, Ltd.
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古川 純康
Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.
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