A New Method for Synthesis of Nucleoside 3', 5'-Cyclic Phosphates. Cyclization of Nucleoside 5'-Trichloromethylphosphonates
スポンサーリンク
概要
- 論文の詳細を見る
The reaction of various nucleosides (III) with trichloromethylphosphonic acid dichloride in triethyl phosphate or m-cresol afforded nucleoside 5'-trichloromethylphosphonates (IV). The intramolecular cyclization of IV with potassium t-butoxide in dimethyl sulfoxide or N, N-dimethylformamide led to the synthesis of nucleoside 3', 5'-cyclic phosphates (I) in high yields by fission of the C-P bond of the phosphonate (IV).
- 社団法人日本薬学会の論文
- 1975-10-25
著者
-
西村 立雄
Medicinal Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
-
丸本 龍二
Central Research Laboratories Takeda Chemical Industries Ltd.
-
本庄 美喜男
Central Research Division, Takeda Chemical Industries, Ltd.
-
西村 立雄
Central Research Division, Takeda Chemical Industries, Ltd.
-
本庄 美喜男
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
-
西村 立雄
Medicinal Research Laboratories Central Research Division Takeda Chemical Industries Ltd.
関連論文
- Synthesis and Antiviral Activities of Carbocyclic Oxetanocin Analogues
- Synthesis of 2-Substituted Adenine-arabinosides and Related Compounds from 5-Amino-4-cyano-1-(β-D-ribofuranosyl)imidazole
- SYNTHESIS OF THE CARBOCYCLIC ANALOGUE OF OXETANOCIN A
- Halogenium-Induced Cyclization of 5-Substituted 6,2'-O-Cyclouridine
- Further Studies on the Reaction of Guanosine Derivatives with Phosphorus Trichloride
- Synthesis of New Cephalosporins with Potent Antibacterial Activities
- Synthesis of 2-Phenylaminoadenosine from Imidazole Nucleosides
- Synthesis and Enzymatic Activity of Adenosine 3', 5'-Cyclic Phosphate Analogs
- Kondensierte Pyrimidine. III. Synthese von Isoxazolo [3,4-d] pyrimidinen
- Synthesis of Aristeromycin Analogs
- A New Method for Synthesis of Nucleoside 3', 5'-Cyclic Phosphates. Cyclization of Nucleoside 5'-Trichloromethylphosphonates
- Synthesis and Coronary Vasodilating Activity of 2-Substituted Adenosines
- Synthesis of Tricyclic Ribonucleosides
- One-Step Halogenation at the 2'-Position of Uridine, and Related Reactions of Cytidine and N^4-Acetylcytidine
- Synthesis of Compounds related to Inosine 5'-Phosphate and Their Flavor Enhancing Activity. IV. 2-Substituted Inosine 5'-Phosphates
- Studies on the Synthesis of Pyrimidine Deoxynucleosides. I. Synthesis of 2', 3'-Dideoxyuridine and 1-(3-Ethylthio-3-deoxy-β-D-xylofuranosyl) uracil
- Structure of 6,3' : 6,5'-Dianhydro-5,5-dibromo-5,6-dihydro-6,6-dihydroxy-1-(β-D-xylofuranosyl) uracil
- Synthesis of Purine Derivatives from Single-carbon Compounds
- A New Reaction of Nucleotides with Cyanoacetylene
- A Direct Synthesis of 3', 5'-Di-O-acetyl-O^2,2'-cyclouridine
- A Novel Method for the Synthesis of Purine Nucleosides using Friedel-Crafts Catalysts
- Synthesis and Physicochemical Properties of 6-O-Cyclopyrimidine Nucleosides
- Synthesis of 8-Carbamoyl- and 8-Carboxyadenosine 3', 5'-Cyclic Phosphates