Synthesis of 2-Substituted Adenine-arabinosides and Related Compounds from 5-Amino-4-cyano-1-(β-D-ribofuranosyl)imidazole

スポンサーリンク

概要

• 論文の詳細を見る

• Triflation of the N^5-benzylidene-3', 5'-O-silyl protected 5-amino-4-cyano-1-(β-D-ribofuranosyl)imidazole (AICN-riboside) (IIb), followed by nucleophilic displacement with OAc^- and N_3^-provided the corresponding 2'(S)-substituted derivatives (VIIa, VIIb). Deprotection of the silyl and benzylidene groups of VIIa, followed by hydrolysis of the acetyl group gave AICN-arabinoside (IXc). Reaction of IXc with alkyl, aryl and aralkyl nitriles afforded the corresponding 2-substituted adenine-arabinosides (XIa-e). The 2'-azido (Xa) and 2'-amino (Xb) analogs of XIa were similarly prepared.

• 社団法人日本薬学会の論文
• 1989-06-25

著者

• 丸山 徳見

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• 佐藤 佳子

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• 本庄 美喜男

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• 佐藤 佳子

  Department Of Pharmaceutical Sciences Tokushima Bunri University

• 本庄 美喜男

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• 丸山 徳見

  徳島文理大 薬

• Sato Yoshiko

  Department Of Pharmaceutical Sciences Tokushima Bunri University

• 丸山 徳見

  Faculty of Pharmaceutical Sciences, Osaka University

関連論文

• 9-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl) adenine の抗ヘルペス作用の検討
• Synthesis and Antiviral Activities of Carbocyclic Oxetanocin Analogues
• Synthesis, Antiviral, Antibacterial and Antitumor Cell Activities of 2'-Deoxy-2'-fluoropuromycin
• Synthesis and Antiviral Activity of 3'-Fluorocarbocyclic Oxetanocin A
• Synthesis and Hypnotic and Anti-Human Immunodeficiency Virus-1 Activities of N^3-Substituted 2'-Deoxy-2'-fluorouridines
• Synthesis and Antiviral Activity of Carbocyclic Oxetanocin Analogues(C-OXT-A, C-OXT-G) and Related Compounds. II
• Synthesis of 2-Substituted Adenine-arabinosides and Related Compounds from 5-Amino-4-cyano-1-(β-D-ribofuranosyl)imidazole
• SYNTHESIS OF THE CARBOCYCLIC ANALOGUE OF OXETANOCIN A
• Halogenium-Induced Cyclization of 5-Substituted 6,2'-O-Cyclouridine
• Further Studies on the Reaction of Guanosine Derivatives with Phosphorus Trichloride
• Synthesis and Enzymatic Activity of Adenosine 3', 5'-Cyclic Phosphate Analogs
• Synthesis of Aristeromycin Analogs
• A New Method for Synthesis of Nucleoside 3', 5'-Cyclic Phosphates. Cyclization of Nucleoside 5'-Trichloromethylphosphonates
• Synthesis and Coronary Vasodilating Activity of 2-Substituted Adenosines
• Synthesis of Tricyclic Ribonucleosides
• One-Step Halogenation at the 2'-Position of Uridine, and Related Reactions of Cytidine and N^4-Acetylcytidine
• Synthesis of Compounds related to Inosine 5'-Phosphate and Their Flavor Enhancing Activity. IV. 2-Substituted Inosine 5'-Phosphates
• Studies on the Synthesis of Pyrimidine Deoxynucleosides. I. Synthesis of 2', 3'-Dideoxyuridine and 1-(3-Ethylthio-3-deoxy-β-D-xylofuranosyl) uracil
• Morphometric Evaluation of Late Normal Tissue Damage after Neon Beam Irradiation in Mouse Hind Legs
• Structure of 6,3' : 6,5'-Dianhydro-5,5-dibromo-5,6-dihydro-6,6-dihydroxy-1-(β-D-xylofuranosyl) uracil
• Synthesis of Purine Derivatives from Single-carbon Compounds
• A New Reaction of Nucleotides with Cyanoacetylene
• A Direct Synthesis of 3', 5'-Di-O-acetyl-O^2,2'-cyclouridine
• A Novel Method for the Synthesis of Purine Nucleosides using Friedel-Crafts Catalysts
• Studies of Nucleosides and Nucleotides. LXXXV. Purine Cyclonucleosides. (35). Synthesis of Purine Nucleosides having 2'-Azido and 2'-Amino Functions by Cleavage of Purine Cyclonucleosides
• Synthesis and Physicochemical Properties of 6-O-Cyclopyrimidine Nucleosides
• Synthesis of 8-Carbamoyl- and 8-Carboxyadenosine 3', 5'-Cyclic Phosphates
• Studies of Nucleosides and Nucleotides. LXXIII. Chlorination of Adenosine and Its N^6-Methyl Derivatives with t-Butyl Hypochlorite
• 抗ヘルペス活性をもつヌクレオシドと作用機序(ヌクレオシドの生物活性) (核酸化学の新展開--新しい機能性分子を求めて) -- (新しい構造と機能を有するヌクレオシドの分子設計)
• 新抗ウイルス剤の分子設計 (ウイルスへの挑戦)
• 新しいエイズ治療薬には耐性ウイルスが出現しやすい?
• アミノヌクレオシドの化学 (〔徳島文理大学〕薬学部特集号)
• Studies of Nucleosides and Nucleotides. LXXIX. Purine Cyclonucleosides. (37). The Total Synthesis of an Antibiotic 2'-Amino-2'-deoxyguanosine
• Studies of Nucleosides and Nucleotides. LXIX. Purine Cyclonucleosides. (30). Elimination of the 8-Oxy Function of Purine Nucleosides
• ロデノシン (FddA) の工業的製法開発

もっと見る 閉じる

スポンサーリンク