Studies of Nucleosides and Nucleotides. LXIX. Purine Cyclonucleosides. (30). Elimination of the 8-Oxy Function of Purine Nucleosides

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概要

• 論文の詳細を見る

• Triacetyl-8-oxyinosine (Ib) was treated with phosphoryl chloride in diethylaniline or thionyl chloride in dimethyl formamide (DMF) to give only 6-chloro-8-oxy compound (IV). Treating (Ib) with phosphoryl chloride in tri-n-butylamine gave 6,8-dichloro compound (VII). Compound (VII) was converted to bis (methylmercapto) compound (VIII) and treated successively with dimethylamine and Raney nickel to give N^6-dimethyladenosine. Thus, a procedure for eliminating 8-oxy function of purine nucleosides has been substantiated.

• 公益社団法人日本薬学会の論文
• 1976-04-25

著者

• 丸山 徳見

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• 丸山 徳見

  Department Of Pharmaceutical Sciences Tokushima Bunri University

• 池原 森男

  Faculty Of Pharmaceutical Sciences Osaka University

• 丸山 徳見

  Faculty of Pharmaceutical Sciences, Osaka University

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