Synthesis and Antiviral Activities of Carbocyclic Oxetanocin Analogues

概要

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9-Cyclobutyladenine (4a), cis- and trans-9-[3-(hydroxymethyl)cyclobutyl]adenine (4b) and 9-[3,3-bis(hydroxymethyl)cyclobutyl]adenine(4d) were prepared from the corresponding cyclobutylamine derivatives (1a, 1b and 1d). Guanine congeners (9a, cis- and trans-9b and 9d) and carbocyclic oxetanocin G (1', 2'-trans-9f) were also prepared. Carbocyclic oxetanocin A(1', 2'-trans-4f), the preparation of which we have already published, and G were found to be active against herpes simplex virus (type 1 and 2) in vitro, while cis-4b and cis-9b showed an in vitro antiretrovial activity against human immunodeficiency virus (type 1).
社団法人日本薬学会の論文
1990-10-25