Polynucleotides. LV. Synthesis and Properties of Dinucleoside Monophosphates derived from Adenine 8,2'-S- and Uracil 6,2'-O-Cyclonucleosides. Further Support for the Left-Handed Stacking of Oligonucleotides having High-Anti Base Torsion Angles
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概要
- 論文の詳細を見る
Two sequence isomers of dinucleoside monophosphates, 8,2'-anhydro-8-thio-9-β-D-arabinofuranosyladenylyl-(3'-5')-6,2'-anhydro-6-oxy-1-β-D-arabinofuranosyluracil (A^spU°) (III) and 6,2'-anhydro-6-oxy-1-β-D-arabinofuranosyluridylyl-(3'-5')-8,2'-anhydro-8-thio-9-β-D-arabinofuranosyladenine (U°pA^s) (IV), were synthesized by condensation of suitably protected nucleoside and nucleotide units using dicyclohexyl carbodiimide as a condensing reagent. Examination of the UV, CD and NMR spectra of these dimers led us to the conclusion that, whereas compound III did not take a stacked conformation, compound IV took a well-stacked conformation, in which the bases were stacked along a left-handed screw axis. The adoption of this conformation could be interpreted in terms of the high base torsion angles in both nucleoside units.
- 社団法人日本薬学会の論文
- 1980-01-25
著者
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上杉 晴一
横浜国立大学工学部
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上杉 晴一
Faculty Of Engineering Yokohama National University
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池原 森男
Faculty of Pharmaceutical Sciences, Osaka University(Present address)
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志田 敏夫
Faculty of Pharmaceutical Sciences, Osaka University
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志田 敏夫
Faculty Of Pharmaceutical Sciences Osaka University
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上杉 精一
Faculty Of Pharmaceutical Sciences Osaka University
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池原 森男
Faculty Of Pharmaceutical Sciences Osaka University
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上杉 晴一
Faculty Of Pharmaceutical Sciences Osaka University
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