Polynucleotides. LXI. Synthesis and Properties of Dinucleoside Monophosphates Containing 8,2'-S-Cycloadenosine and 8,2'-S-Cycloinosine Residues. Sequence Dependency of the Stability of the Stacking Conformation
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概要
- 論文の詳細を見る
Three dinucleoside monophosphates containing 8,2'-anhydro-8-thio-9-β-D-arabinofuranosyladenine (A^s) and its hypoxanthine derivative (I^s), A^spI^s, I^spA^s and I^spI^s, were synthesized. Examination of their properties by ultraviolet absorption, circular dichroism and ^1H nuclear magnetic resonance measurements and comparison with the properties of A^spA^s, which has been shown to take a left-handed stacked conformation, showed that all these dimers take a left-handed stacked conformation, and the order of extent of stacking is A^spA^s≈I^spA^s>A^spI^s≈I^spI^s. This sequence dependency of stability of stacking can be explained in terms of the mode of base-base overlap in a left-handed stack. A similar explanation may be applicable to the corresponding sequence dependency of natural dimers with a right-handed stack.
- 社団法人日本薬学会の論文
- 1980-12-25
著者
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上杉 晴一
横浜国立大学工学部
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上杉 晴一
Faculty Of Engineering Yokohama National University
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池原 森男
Faculty of Pharmaceutical Sciences, Osaka University(Present address)
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志田 敏夫
Faculty of Pharmaceutical Sciences, Osaka University
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志田 敏夫
Faculty Of Pharmaceutical Sciences Osaka University
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上杉 精一
Faculty Of Pharmaceutical Sciences Osaka University
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池原 森男
Faculty Of Pharmaceutical Sciences Osaka University
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上杉 晴一
Faculty Of Pharmaceutical Sciences Osaka University
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