Studies of Nucleosides and Nucleotides. LXXXIV. Purine Cyclonucleosides. XL. Cyclonucleosides derived from 5´-Deoxyadenosine
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概要
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5´-Deoxyadenosine (I) was brominated at the 8-position and converted to 8,2´-(VI) and 8,3´-S-cyclonucleosides (VII) via the 2´, 3´-dibutylstannylene compound by successive tosylation and heating with NaSH. When VI was treated with tert-butyl hypochlorite, an exo sulfoxide VIII was obtained. Desulfurization of VI and VII with Raney Ni gave 2´, 5´-(IX) and 3´, 5´-dideoxyadenosine (X), respectively. An 8,2´-O-cyclonucleoside (XII) was also obtained from V by a standard procedure. Rearrangement of XII to a ribo-type epoxide (XIII) in the presence of 0.1 N NaOH was observed.
- 公益社団法人日本薬学会の論文
- 1979-11-25
著者
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池原 森男
Faculty of Pharmaceutical Sciences, Osaka University(Present address)
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長谷川 明
Faculty of Pharmaceutical Sciences, Osaka University
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長谷川 明
Faculty Of Pharmaceutical Sciences Osaka University
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三木 弘子
Faculty of Pharmaceutical Sciences, Osaka University
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三木 弘子
Faculty Of Pharmaceutical Sciences Osaka University
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池原 森男
Faculty Of Pharmaceutical Sciences Osaka University
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