Studies on Coenzyme Analogs. XVII. A New Synthesis of Purine Nucleoside by the Condensation of Chloropyrimidine with Glucosylamine.
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概要
- 論文の詳細を見る
The reaction between 4,6-dichloro-5-nitropyrimidine or 4-amino-5-nitro-6-chloropyrimidine and 2,3,4,6-tetra-O-acetyl-D-glucopyranosylamine was investigated. In the former case, in addition to 4-chloro-5-nitro-6-(2,3,4,6-tetra-O-acetylglucosylamino) pyrimidine, 4,6-bis-glucosylamino derivative was obtained. Ring-closure of 4-chloro-5-amino-6-(2,3,4,6 tetra-O-acetylglucosylamino) pyrimidine was achieved by acetic anhyd. ethyl orthoformate and further two step reaction afforded 9-β-D-glucopyranosyladenine. By the carbon disulfide ring-closure of 4,5-diamino-6-(2,3,4,6-tetra-O-acetylglucosylamino) pyrimidine, 9-β-D-glucosyladenine and N^6-glucosyladenine was obtained in the ratio of 2 : 9. After deacetylation of triaminopyrimidine derivative, however, the reaction occurred in the reversed ratio of 9 : 4.
- 社団法人日本薬学会の論文
- 1963-09-25
著者
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池原 森男
Faculty of Pharmaceutical Sciences, Osaka University(Present address)
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多田 宏
Faculty Of Pharmaceutical Sciences Hokkaido University
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池原 森男
Faculty Of Pharmaceutical Sciences Osaka University
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