Studies of Nucleosides and Nucleotides. LXXXII. Cyclonucleosides. (39). Synthesis and Properties of 2'-Halogeno-2'-deoxyadenosines
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概要
- 論文の詳細を見る
9-(2'-O-Methanesulfonyl- or trifluoromethanesulfonyl-3', 5'-di-O-tetrahydropyranyl-β-D-arabinofuranosyl) adenine (Ia, b) were reacted with lithium chloride or tetrabutylammonium halide to yield 2'-halogeno-2'-deoxy compounds (IIa-d). These halogeno compounds were deprotected with 80% acetic acid to give 2'-chloro-, 2'-bromo-, 2'-fluoro and 2'-iodo-2'-deoxyadenosine (IVa-d) in overall yields of 12-25% from the compound I. Ultraviolet absorption properties, ^1H and ^<13>C-nuclear magnetic resonance spectral properties were recorded on the compounds IVa-d.
- 公益社団法人日本薬学会の論文
- 1978-08-25
著者
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池原 森男
Faculty of Pharmaceutical Sciences, Osaka University(Present address)
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三木 弘子
Faculty of Pharmaceutical Sciences, Osaka University
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三木 弘子
Faculty Of Pharmaceutical Sciences Osaka University
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池原 森男
Faculty Of Pharmaceutical Sciences Osaka University
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