A NEW SYNTHETIC METHOD FOR 5'-TRIPHOSPHORYL-ADENYLYL-(2'-5')-ADENYLYL-(2'-5')-ADENOSINE (2-5A) AND 2-5A CORE USING 3'-O-TETRAHYDROFURANYL-ADENOSINE DERIVATIVES

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概要

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• 2' or 3'-O-Tetrahydrofuranyl derivatives of ribonucleosides have been synthesized by treating 2,3-dihydrofurane with bis tert-butyldi-methylsilyl N-protected nucleosides. Using 3'-O-tetrahydrofuranyl-N-benzoyladenosine as the starting meterial 5'-phosphoryladenylyl-(2'-5')-adenylyl-(2'-5')-adenosine was synthesized in a good yield and converted to the triphosphoryl derivative (2-5A). The 2'-5' linked triadenylate (2-5A core) was also prepared by the same phosphotriester method.

• 社団法人日本薬学会の論文
• 1982-01-25

著者

• 池原 森男

  Faculty of Pharmaceutical Sciences, Osaka University(Present address)

• 大塚 栄子

  Faculty of Pharmaceutical Sciences, Osaka University

• 大塚 栄子

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 山根 明男

  Faculty of Pharmaceutical Sciences, Osaka University

• 山根 明男

  Faculty Of Pharmaceutical Sciences Osaka University

• 池原 森男

  Faculty Of Pharmaceutical Sciences Osaka University

関連論文

• Activity of Artificial Mutant Variants of Human Growth Hormone Changes in Charged Residues around 62-67
• Activity of Artificial Mutant Variants of Human Growth Hormone Deficient in a Disulfide Bond between Cys53 and Cys165
• Synthesis of 8,5'-Anhydro-8-mercaptoadenosine
• Synthesis of 8,5'-Anhydro-8-mercaptoadenosine
• Synthesis of 8,5'-Anhydro-8-mercaptoadenosine
• Synthesis of 8,5'-Anhydro-8-mercaptoadenosine
• Studies on tRNA and Related Compounds. XXXVII. Synthesis and Physical Properties of 2'- or 3'-O-(o-Nitrobenzyl) nucleosides : the Use of o-Nitrophenyldiazomethane as a Synthetic Reagent
• Studies on Transfer Ribonucleic Acids and Related Compounds. XVI. Synthesis of Ribooligonucleotides using a Photosensitive o-Nitrobenzyl Protection for the 2'-Hydroxyl Group
• Studies on tRNA and Related Compounds. XXXVII. Synthesis and Physical Properties of 2'- or 3'-O-(o-Nitrobenzyl) nucleosides : the Use of o-Nitrophenyldiazomethane as a Synthetic Reagent
• Studies on Transfer Ribonucleic Acids and Related Compounds. XVI. Synthesis of Ribooligonucleotides using a Photosensitive o-Nitrobenzyl Protection for the 2'-Hydroxyl Group
• Molecular Dynamics and Free Energy Perturbation Calculations on the Mutation of Tyrosine 45 to Tryptophan in Ribonuclease T_1
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• Synthesis of a Gene Coding for Human Lysozyme
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• Polynucleotides. LXI. Synthesis and Properties of Dinucleoside Monophosphates Containing 8,2'-S-Cycloadenosine and 8,2'-S-Cycloinosine Residues. Sequence Dependency of the Stability of the Stacking Conformation
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• Purification and Characterization of the Product of Chemically Synthesized Human Growth Hormone Gene Expression in Escherichia coli(Biological,Chemical)
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• Studies on Transfer Ribonucleic Acids (tRNA) and Related Compounds. XLIX. Solid-Phase Synthesis of Nonadecaribonucleotide Corresponding to the 5'-Half of the Formylmethionine tRNA Deficient in D-Loop and Stem Region
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• A NEW SYNTHETIC METHOD FOR 5'-TRIPHOSPHORYL-ADENYLYL-(2'-5')-ADENYLYL-(2'-5')-ADENOSINE (2-5A) AND 2-5A CORE USING 3'-O-TETRAHYDROFURANYL-ADENOSINE DERIVATIVES
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• Studies of Nucleosides and Nucleotides. XXXIX. Synthesis of 8-Substituted Purine Nucleotides by the Direct Replacement Reactions
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• Polynucleotides. XII. Synthesis and Properties of Dinucleoside Monophosphates containing 8-Bromoadenosine
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• Synthesis of 3'-5'-Internucleotidic Linkage by the Use of Dimethyl-formamide-Thionyl Chloride Complex as Condensing Agent
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