Synthesis of 8-Carbamoyl- and 8-Carboxyadenosine 3', 5'-Cyclic Phosphates
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概要
- 論文の詳細を見る
The reaction of 8-bromo-cAMP (cAMP : adenosine 3', 5'-cyclic phosphate) (I) with potassium cyanide in hot dimethylformamide (DMF) afforded 8-carbamoyl-cAMP (IV). Compound IV was hydrolyzed with aqueous sodium hydroxide to 8-carboxy-cAMP (VI), which was converted to cAMP by heating in dimethylsulfoxide. A similar reaction of 8-bromo-5'-AMP (II) or 8-bromo-2', 3'-O-isopropylideneadenosine (VII) with potassium cyanide in DMF yielded 8-bromoadensine or 8,5'-anhydro-2', 3'-O-isopropylidene-8-oxyadenosine (VIII) respectively. The treatment of 5'-nucleotides with hot aqueous DMF afforded the corresponding nucleosides in high yields.
- 公益社団法人日本薬学会の論文
- 1976-09-25
著者
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本庄 美喜男
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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本庄 美喜男
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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仲 建彦
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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