Further Studies on the Reaction of Guanosine Derivatives with Phosphorus Trichloride
スポンサーリンク
概要
- 論文の詳細を見る
Reaction of 2', 3'-di- or 2', 3', 5'-tri-O-protected guanosine (I, IX) with phosphorus trichloride in ethyl methyl ketone, cyclohexanone or benzaldehyde afforded the corresponding N^2-(1-phosphono)alkylguanosine derivative (IIa-c). The structure of the aglycon (IIIa) was determined definitely by the X-ray diffraction method. A similar reaction in dioxane resulted in no modification of the guanine moiety, while the reaction in tetrahydrofuran gave 4-(inosin-2-yl)amino-4-phosphonobutyl hydrogen phosphonate (VII). None of the reactions in acetylacetone, benzoquinone, naphthoquinone and anthraquinone modified the guanine base. An alternative preparation of guanosine 5'-monophosphate was accomplished by the reaction of isopropylideneguanosine(IX) with phosphorus trichloride in anthraquinone in a stream of oxygen, followed by hydrolysis and deblocking.
- 社団法人日本薬学会の論文
- 1986-02-25
著者
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冨田 研一
Faculty of Pharmaceutical Sciences, Osaka University
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大石 宏文
Osaka University of Pharmaceutical Sciences
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藤原 隆二
Faculty of Pharmaceutical Sciences, Osaka University
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佐藤 佳子
Department Of Pharmaceutical Sciences Tokushima Bunri University
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丸山 徳見
School of Pharmacy, Tokushima Bunri University
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佐藤 佳子
School of Pharmacy, Tokushima Bunri University
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本庄 美喜男
School of Pharmacy, Tokushima Bunri University
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大石 宏文
Faculty of Pharmaceutical Sciences, Osaka University
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小川 恵三
Faculty of Pharmaceutical Sciences, Osaka University
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藤原 隆二
Faculty Of Pharmaceutical Sciences Osaka University
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本庄 美喜男
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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冨田 研一
Faculty Of Pharmaceutical Sciences Osaka University
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丸山 徳見
徳島文理大 薬
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小川 恵三
Faculty Of Pharmaceutical Sciences Osaka University
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Sato Yoshiko
Department Of Pharmaceutical Sciences Tokushima Bunri University
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