Synthesis of Compounds related to Inosine 5'-Phosphate and Their Flavor Enhancing Activity. IV. 2-Substituted Inosine 5'-Phosphates
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概要
- 論文の詳細を見る
Ring closure of 5-amino-1-β-D-ribofuranosylimidazole-4-carboxamide (AICA-riboside) with phenyl isothiocyanate afforded 2-mercaptoinosine (I) in good yield. Similarly, the ring closure of AICA-riboside 5'-phosphate (AICAR) led to the formation of 2-mercaptoinosine 5'-phosphate (II). Various 2-substituted inosine 5'-phosphates were prepared from I and II or starting with AICA-riboside. It was found that 2-furfuryl-thioinosine 5'-phosphate possessed a flavor enhancing activity of about 17-times that of inosine 5'-phosphate. The chemical structure-flavor enhancing activity relationship was presented.
- 社団法人日本薬学会の論文
- 1971-03-25
著者
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本庄 美喜男
Research Laboratories, Takeda Chemical Industries, Ltd.
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小林 邦夫
Diagnostic Science Department Shionogi & Co. Ltd.
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今井 欣一
Research Laboratories, Takeda Pharmaceutical Iudustries, Ltd.
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丸本 龍二
Central Research Laboratories Takeda Chemical Industries Ltd.
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丸本 龍二
Research and Development Division, Takeda Chemical Industries, Ltd.
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小林 邦夫
Research and Development Division, Takeda Chemical Industries, Ltd.
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吉岡 義夫
Research and Development Division, Takeda Chemical Industries, Ltd.
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戸田 準
Research and Development Division, Takeda Chemical Industries, Ltd.
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吉岡 義夫
Central Research Division Takeda Chemical Ind. Ltd.
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今井 欣一
Animal Health Products Division Takeda Chemical Industries Ltd.
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本庄 美喜男
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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戸田 準
Research And Development Division Takeda Chemical Industries Ltd.
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