Anticoccidials. VII. Synthesis of 4,5-Dihydro-5-oxo-2-pyrazinecarboxylic Acid 1-Oxides
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概要
- 論文の詳細を見る
Hydrolysis of 1,6-dihydro-6-oxo-2,3-pyrazinedicarbonitrile (4) gave sodium hydrogen 1,6-dihydro-6-oxo-2,3-pyrazinedicarboxylate (6), which was converted to methyl 1,6-dihydro-6-oxo-2-pyrazinecarboxylate (10) and methyl 4,5-dihydro-5-oxo-2-pyrazine-carboxylate (12) via a sequence of reactions including decarboxylation and esterification. Although the synthesis of 4,5-dihydro-5-oxo-2-pyrazinecarboxylic acid 1-oxide (2) from 12 was unsuccessful, its 6-methyl derivative 3 was synthesized from the 5-methyl analog of 4.
- 社団法人日本薬学会の論文
- 1980-10-25
著者
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瀬尾 卓司
Animal Health Products Division Takeda Chemical Industries Ltd.
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今井 欣一
Animal Health Products Division Takeda Chemical Industries Ltd.
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真野 光彦
Animal Health Products Division, Takeda Chemical Industries, Ltd.
関連論文
- Studies on Nucleic Acid Antagonists. I. Syntheses of 5-Phenylazopyrimidines.
- Synthesis and Coronary Vasodilating Activity of 2-Substituted Adenosines
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- Synthesis of 6-Methylaminopurine by Thermal Cyclization of 4,6-Bis (methylamino) -5-phenylazopyrimidine
- Anticoccidials. VI. An Improved Synthesis of 1,6-Dihydro-6-oxo-2-pyrazinecarboxylic Acid 4-Oxide and Some Related Derivatives and Determination of Anticoccidial Activity
- Anticoccidials. VII. Synthesis of 4,5-Dihydro-5-oxo-2-pyrazinecarboxylic Acid 1-Oxides
- Anticoccidials. V. Synthesis and Anticoccidial Activity of 2(1H)-Pyrazinone 4-Oxide Derivatives
- Anticoccidials. IV. A Convenient Synthesis of 2(1H)-Pyrazinone 4-Oxide Derivatives
- Anticoccidials. II. Autoxidation and Structural Determination of 1-Benzylamino-3-substituted Guanidines
- Anticoccidials. I. Syntheses and Anticoccidial Activity of 2-Amino-5-aryl-1,3,4-oxadiazoles, 5-Alkoxy-3-aryl-1H-1,2,4-triazoles, and 3-Aryl-⊿^2-1,2,4-triazolin-5-ones
- Structure-Activity Relationship in the Taste Effect of Ribonucleotide Derivatives
- Studies on the Synthesis of Pyrimidine Deoxynucleosides. I. Synthesis of 2', 3'-Dideoxyuridine and 1-(3-Ethylthio-3-deoxy-β-D-xylofuranosyl) uracil
- Synthesis of Purine Nucleosides Using Iodine as Catalyst
- Synthesis of the Glucose Analogs of Inosine-5' Phosphate.
- Synthesis of 5-Substituted Pyrimidine Nucleosides
- Studies on Nucleic Acid Antagonists. VII. Synthesis and Characterization of 1,4,6-Triazaindenes (5H-Pyrrolo[3,2-d]pyrimidines)
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- Synthesis of Uridine Diphosphate-Glucuronic Acid.
- Synthesis of Uridine Diphosphate-Glucuronic Acid