Synthesis of Cytidine 5'-Diphosphate-and Deoxycytidine 5'-Diphosphate-L-serine
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概要
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O-Phosphoryl-L-serine (I) was treated with carbobenzyloxychloride to give O-phosphoryl-N-carbobenzyloxy-L-serine (III). Condensation of III with dicyclohexylguanidinium cytidine 5'-phosphoramidate (II) gave cytidine 5'-diphosphate-N-carbobenzyloxy-L-serine (IV), which was hydrogenated with palladised charcoal to obtain cytidine 5'-diphophate-L-serine. Likewise, deoxycytidine 5'-diphosphate-L-serine was synthesized from III and dicyclohexylguanidinium deoxycytidine 5'-phosphoramidate (V).
- 社団法人日本薬学会の論文
- 1965-01-25
著者
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水野 芳子
Research Laboratories Takeda Chemical Industries Ltd.
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古川 純康
Research Laboratories, Takeda Chemical Industries, Ltd.
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三野 安
Research Laboratories, Takeda Chemical Industries, Ltd.
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本庄 美喜男
Research Laboratories, Takeda Chemical Industries, Ltd.
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三野 安
Central Research Division, Takeda Chemical Industries, Ltd.
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古川 純康
Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.
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三野 安
Central Research Division Takeda Chemical Industries Ltd.
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