Syntheses and β-Adrenoceptor Activities of 2-Alkylamino-6-hydroxy-5-hydroxymethyl-1,2,3,4-tetrahydro-1-naphthalenols

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概要

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• In connection with our earlier studies on β-adrenergic-stimulating activities of ringclosed analogs of β-hydroxycatecholamines, a series of 2-amino-and 2-alkylamino-1,2,3,4-tetrahydro-1-naphthalenols was synthesized with the aim of finding new bronchodilators with minimal cardiovascular side effects. The present paper includes compounds possessing a hydroxy group at the 6-position and a hydroxymethyl, cyano or ureidomethyl group at the 5-position. As starting materials, 6-methoxy-3,4-dihydro-1 (2H)-naphthalenone and methyl 2-hydroxy-1-naphthoate were used. The latter was more advantageous for the synthesis of 5-hydroxymethyl derivatives. Stereoselective reduction of the 1-ketone to give cis-or trans-2-amino-1-hyroxy compounds was also discussed.

• 社団法人日本薬学会の論文
• 1977-11-25

著者

• 杉原 弘貞

  Central Research Division, Takeda Chemical Industries, Ltd.,

• 鵜川 清

  Central Research Division, Takeda Chemical Ind., Ltd.,

• 西川 正夫

  Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.

• 栗木 久

  Central Research Division Takeda Chemical Industries Ltd.

• 西川 正夫

  Central Research Division, Takeda Chemical Industries, Ltd.

• 三野 安

  Central Research Division, Takeda Chemical Industries, Ltd.

• 杉原 弘貞

  Pharamaceutical Research Laboratories I Pharmaceutical Research Division Takeda Chemical Industries

• 杉原 弘貞

  Central Research Division Takeda Chemical Industries. Ltd.

• 西川 正夫

  Central Research Division Takeda Chemical Industries Ltd.

• 鵜川 清

  Resarch & Development Division Takeda Chemical Industries Ltd.

• 三野 安

  Central Research Division Takeda Chemical Industries Ltd.

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