Synthesis of (3-Carboxy-5-oxo-5H-[1]benzopyrano[2,3-b]pyridin-2-yl)acetic Acid Derivatives, Potential Antiarthritic Agents
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概要
- 論文の詳細を見る
(3-Carboxy-5-oxo-5H[1]benzopyrano[2,3-b]pyridin-2-yl)acetic acid derivatives (3 and 4) were found to possess potent antiarthritic activity in the rat adjuvant arthritis model. The mode of action of these compounds differs from that of acidic antiinflammatory drugs. Various modifications in these compounds (e.g., elongation, removal, or substitution of the methylene group of the acetic acid moiety; and substitution of the benzene ring) were made in order to study the structure-activity relationships. However, it was found that the structural requirements for the compounds to show activity are rather severe.
- 公益社団法人日本薬学会の論文
- 1986-03-25
著者
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鵜川 清
Central Research Division, Takeda Chemical Ind., Ltd.,
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野原 昭
Central Research Division, Takeda Chemical Industries, Ltd.
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葛聲 成二
Central Research Division Takeda Chemical Industries Ltd.
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鵜川 清
Resarch & Development Division Takeda Chemical Industries Ltd.
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久保 恵司
Research And Development Division Takeda Chemical Industries Ltd.
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野原 昭
Research and Development Division, Takeda Chemical Industries, Ltd.,
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久保 恵司
Central Research Division, Takeda Chemical Industries, Ltd.,
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野原 昭
Research And Development Division Takeda Chemical Industries Ltd.
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