Synthesis of 2-[[(4-Fluoroalkoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazoles as Antiulcer Agents
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概要
- 論文の詳細を見る
Many 2-[[(4-fluoroalkoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazoles were synthesized and tested for antisecretory, antiulcer, and cytoprotective activities. Most of these compounds were superior to omeprazole in antisecretory and antiulcer potencies, and especially in protecting the gastric mucosa from ethanol-induced damage. Among these compounds 2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole, AG-1749 (lansoprazole) (6f), was selected for further development and clinical evaluation.
- 公益社団法人日本薬学会の論文
- 1990-10-25
著者
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佐藤 宏
Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.,
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佐藤 宏
Central Research Laboratories Zeria Pharmaceutical Co. Ltd.
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久保 恵司
Research And Development Division Takeda Chemical Industries Ltd.
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小田 克明
Research and Development Division, Takeda Chemical Industries, Ltd.,
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金児 龍彦
Research and Development Division, Takeda Chemical Industries, Ltd.,
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佐藤 宏
Research and Development Division, Takeda Chemical Industries, Ltd.,
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野原 昭
Research and Development Division, Takeda Chemical Industries, Ltd.,
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野原 昭
Research And Development Division Takeda Chemical Industries Ltd.
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小田 克明
Research And Development Division Takeda Chemical Industries Ltd.
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金児 龍彦
Research And Development Division Takeda Chemical Industries Ltd.
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