Synthesis of Quinones having Carboxy- and Hydroxy-Alkyl Side Chains, and Their Effects on Rat-Liver Lysosomal Membrane

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概要

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• In order to study the structure activity relationship of metabolites of ubiquinone, α-tocopherol and phylloquinone (Ia, b, c, IIa, b, c), 3-carboxy-2-butenyl (IIIa, b, c), 6-hydroxy-3-methyl-2-hexenyl (IVa, b, c), 4-hydroxy-3-methylbutyl (Va, b), 4-hydroxy-3-methyl-2-butenyl (VIb, c), ω-carboxyalkyl (VIIa, b, c), and ω-hydroxyalkyl (VIIIa, b) side chains were introduced into the 6-position of 2,3-dimethoxy-5-methyl-1,4-benzoquinone and 2,3,5-trimethyl-1,4-benzoquinone, as well as the 3-position of 2-methyl-1,4-naphthoquinone. The effects of these quinones on the membrane stability of rat-liver lysosomes and on the activity of bovine heart phosphodiesterase were investigated. A good correlation was observed between these activities of the benzoquinone derivatives (VIIa, b).

• 公益社団法人日本薬学会の論文
• 1982-08-25

著者

• 後藤 義一

  Central Research Division, Takeda Chemical Industries, Ltd.

• 渡辺 正純

  Central Research Division, Takeda Chemical Industries, Ltd.

• 川田 満

  Central Research Division, Takeda Chemical Industries, Ltd.

• 今田 伊助

  Central Research Division, Takeda Chemical Industries, Ltd.

• 後藤 義一

  Pharmaceutical Research Laboratories I Pharmaceutical Research Division Takeda Chemical Industries L

• 岡本 加世子

  Central Research Division, Takeda Chemical Industries, Ltd.

• 森本 浩

  Central Reseach Division Takeda Chemical Industries Ltd.

• 芦田 康子

  Central Research Division Takeda Chemical Industries Ltd.

• 今田 伊助

  Central Reseach Division Takeda Chemical Industries Ltd.

• 川田 満

  Central Research Division Takeda Chemical Industries Ltd.

• 渡辺 正純

  Central Reseach Division Takeda Chemical Industries Ltd.

• 小田 克明

  Central Research Division, Takeda Chemical Industries, Ltd.

• 矢島 明子

  Central Research Division, Takeda Chemical Industries, Ltd.

• 岡本 加世子

  Central Reseach Division Takeda Chemical Industries Ltd.

• 小田 克明

  Research And Development Division Takeda Chemical Industries Ltd.

• 矢島 明子

  Central Research Division Takeda Chemical Industries Ltd.

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