A Stereoselective Synthesis and Nuclear Magnetic Resonance Spectral Study of Four Epimeric 17-Hydroxy-16-ethylestranes
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概要
- 論文の詳細を見る
Four epimeric 17-hydroxy-16-ethylestr-4-en-3-ones (11) having potent antiandrogenic activity were prepared stereoselectively starting from 16α-ethyl-16β, 17β-diol monoacetate (2). The nuclear magnetic resonance spectra of the four epimers and other 16-substituted estranes and androstanes were investigated in order to elucidate the possibility for the assignment of the unknown configurations at the positions of 16 and 17. The data of the coupling constants (J_<16,17>) and the chemical shifts (13-methyl protons and 17-proton) can be used for the determination of the configuration at the positions of 16 and 17.
- 社団法人日本薬学会の論文
- 1977-06-25
著者
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吉岡 晃一
Central Research Division, Takeda Chemical Industries, Ltd.
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後藤 義一
Central Research Division, Takeda Chemical Industries, Ltd.
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平賀 謙太郎
Central Research Division, Takeda Chemical Industries, Ltd.
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三木 卓一
Central Research Division, Takeda Chemical Industries, Ltd.
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吉岡 晃一
Central Research Division Takeda Chemical Industries Ltd.
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平賀 謙太郎
武田薬品工業株式会社中央研究所
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後藤 義一
武田薬品工業(株)中央研究所
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三木 卓一
武田薬品工業株式会社中央研究所
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