Dimethyl 5-Hydroxy-6-methylcinchomeronateからPyrido [3,4-d]-pyridazineおよびα-Styrylpyridazine誘導体の合成
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概要
- 論文の詳細を見る
Pyrido [3,4-d] pyridazine derivatives were synthesized from dimethyl 5-hydroxy-6-methylcinchomeronate (I). 8-Hydroxy-7-methylpyrido [3,4-d] pyridazine-1,4-(2H, 3H)-dione (II) was found to produce a strong chemiluminescence and 8-methoxy-7-methyl-1,4-dimorpholinopyrido [3,4-d] pyridazine (IX) had a diuretic activity. α-Styrylpyridine and benzimidazoylpyridine derivatives were also prepared. Dimethyl 5-methoxy-6-styrylcinchomeronate (XVa) and dimethyl 6-(p-chlorostyryl)-5-methoxy-cinchomeronate (XVb) showed a fluorescent whitening action.
- 公益社団法人日本薬学会の論文
- 1972-06-25
著者
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三木 卓一
武田薬品工業株式会社中央研究所
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三木 卓一
武田薬品工業株式会社研究開発本部
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松尾 泰介
武田薬品工業株式会社研究開発本部
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三木 卓一
武田薬品工業 (株) 化学研究所
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松尾 泰介
武田薬品工業 (株) 化学研究所
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