Synthesis and Antiandrogenic Activity of 16β-Substituted-17β-hydroxysteroids
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概要
- 論文の詳細を見る
In order to examine the antiandrogenic activity, a series of 16β-substituted-17β-hydroxysteroids (9 and 16) were synthesized by stereoselective introduction of β-substituents at position 16 of steroids. The corresponding 6-chloro-16β-substituted-17β-hydroxysteroids (20 and 28) and 1,2α-methylene derivative (36) were also prepared. Among these new steroids synthesized, 17β-hydroxy-16β-ethylestr-4-en-3-one (9b : TSAA-291) was found to have the most potent antiandrogenic activity with very weak side effects and also found to be useful for a treatment of the benign prostatic hypertrophy.
- 社団法人日本薬学会の論文
- 1978-06-25
著者
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増岡 通夫
武田薬品工業株式会社中央研究所
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吉岡 晃一
Central Research Division, Takeda Chemical Industries, Ltd.
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後藤 義一
Central Research Division, Takeda Chemical Industries, Ltd.
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平賀 謙太郎
Central Research Division, Takeda Chemical Industries, Ltd.
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三木 卓一
Central Research Division, Takeda Chemical Industries, Ltd.
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中山 亮
武田薬品工業株式会社中央研究所
-
吉岡 晃一
Central Research Division Takeda Chemical Industries Ltd.
-
平賀 謙太郎
武田薬品工業株式会社中央研究所
-
中山 亮
Central Research Division, Takeda Chemical Industries Ltd.
-
後藤 義一
武田薬品工業(株)中央研究所
-
三木 卓一
武田薬品工業株式会社中央研究所
-
増岡 通夫
Central Research Division, Takeda Chemical Industries, Ltd.
-
中山 亮
Central Research Division Takeda Chemical Industries Ltd.
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