A Phosphorylation of Steroids and a Dienone-Phenol Rearrangement leading to a Secosteroidal Aldehyde Which has a Strong Toxicity
スポンサーリンク
概要
- 論文の詳細を見る
By the use of pyrophosphoryl chloride, 21-hydroxy-20-oxosteroids were phosphorylated in one step in quantitative yield. When the reaction was carried out on prednisolone at a higher temperature, a dienonephenol rearrangement and a simultaneous pinacolic shift took place resulting in the formation of 3,21-diphosphate of C-nor-9,10-secosteroidal aldehyde (A) as a by-product. This compound showed a cardioinhibitory and vasoconstricting activity and a strong toxicity to rabbits.
- 社団法人日本薬学会の論文
- 1974-07-25
著者
-
平賀 謙太郎
武田薬品工業株式会社中央研究所
-
川井 清尚
甲子園大学栄養学部
-
三木 卓一
武田薬品工業株式会社中央研究所
-
菊地 健三
Central Research Division, Takeda Chemical Industries, Ltd.
-
YAMAZAKI MINORU
Quality Testing Department of Osaka Plant, Takeda Chemical Industries, Ltd.
-
Yamazaki Minoru
Quality Testing Department Of Osaka Plant Takeda Chemical Industries Ltd.
-
桝屋 浩大
Central Research Division Takeda Chemical Ind. Ltd.
-
菊地 健三
Central Research Division Takeda Chemical Industries Ltd.
関連論文
- Studies on Antiandrogenic Agents. Synthesis of 16β-Ethyl-19-nortestosterone
- 17-Deoxysteroid類の合成と抗男性ホルモン作用
- 16β-Ethyl-17β-hydroxyestr-4-en-3-one(Oxendolone)の別途合成
- Synthesis and Antiandrogenic Activity of 16β-Substituted-17β-hydroxysteroids
- A Stereoselective Synthesis and Nuclear Magnetic Resonance Spectral Study of Four Epimeric 17-Hydroxy-16-ethylestranes
- A Phosphorylation of Steroids and a Dienone-Phenol Rearrangement leading to a Secosteroidal Aldehyde Which has a Strong Toxicity
- 全合成法による19-Nortestosterone同族体の合成
- Total Synthesis of 13β-Allylgonanes. III
- Total Synthesis of 13β-Allylgonanes. II
- Total Synthesis of 13β-Allylgonanes. I. Synthesis of dl-17α-Ethynyl-17β-hydroxy-13β-allylgon-4-en-3-one
- γ-ケトアルコール類とDiethyl Oxalateとの反応について
- A Stereoselective Synthesis of 16β-Substituted-17-oxosteroids
- 16-エチル置換ステロイドの全合成
- The Structure of 9,14-Epoxy-8,14-seco Steroids
- Total Synthesis of Estrone via Estriol Dimethyl Ether
- rac-3-(3-Oxo-17β-hydroxy-13-ethylgon-4-en-17α-yl)-propionic Acid γ-Lactoneの全合成
- An Improved Synthesis of optically Active Steroids
- New Synthesis of 2-Substituted Cyclopentane-1,3-dione
- Syntheses and Steric Hindrances in 13β-Isopropylgonanes
- An Improved Synthesis of Estrogens.
- 1,6-trans-N, N-Dimethyl-(6-benzyl-4,4-dimethyl-2-cyclohexenyl)methylamine塩酸塩(TAI-998)の鎮痛作用
- Synthesis of Cephalosporins with Substituted Thiadiazoles directly attached to the C_3-Position. I. Synthesis of 3-(5-Substituted-1,3,4-thiadiazol-2-yl) ceph-3-em Derivatives
- Synthesis of 3-Carboxyceph-3-em Compounds and Reactions of Cephalosporin Thiolactones
- Synthesis of Cephalosporins with Substituted Thiadiazoles directly attached to the C_3-Position
- Dimethyl 5-Hydroxy-6-methylcinchomeronateからPyrido [3,4-d]-pyridazineおよびα-Styrylpyridazine誘導体の合成
- ビタミンB_6同族体の合成
- Synthesis and Antibacterial Activity of 3-Acylamino-3-methoxy-2-azetidinone-1-sulfonic Acid Derivatives
- Synthesis and Antibacterial Activity of 3-Acylamino-2-azetidinone-1-sulfonic Acid Derivatives
- A New Synthetic Method of 3-Formylcephalosporins