Total Synthesis of 13β-Allylgonanes. II
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概要
- 論文の詳細を見る
In order to protect selectively the double bond of the allyl group at C-13 in 3-methoxy-13-allyl-8,14-secogona-1,3,5 (10), 9-tetraene-14,17-dione (I), the authors established the synthesizing route via 9α, 14α-epoxy-3-methoxy-13β-allyl-8,14-secogona-1,3,5 (10)-trien-17-one (IV), which was converted into the diol (VI) or the dibromide (XXVI). Reaction of VI with acetic anhydride and p-toluenesulfonic acid gave the gonapentaene triacetate (X), but treatment of VI with hydrochloric acid in methanol yielded a novel steroid (VIII).
- 社団法人日本薬学会の論文
- 1973-10-25
著者
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吉岡 晃一
Central Research Division, Takeda Chemical Industries, Ltd.
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吉岡 晃一
Central Research Division Takeda Chemical Industries Ltd.
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平賀 謙太郎
武田薬品工業株式会社中央研究所
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平賀 謙太郎
Chemical Research Laboratories Research & Development Division Takeda Chemical Industries Ltd.
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後藤 義一
Chemistry Research Laboratories
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後藤 義一
武田薬品工業(株)中央研究所
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三木 卓一
武田薬品工業株式会社中央研究所
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吉岡 晃一
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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三木 卓一
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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