Syntheses of Racemic and Optically Active 13β-Ethylgonanes.
スポンサーリンク
概要
- 論文の詳細を見る
During the course of the synthesis of 18-methylestradiol 3-methyl ether, steric effect caused by the methyl group at 18-position was observed. It was found that ethylenediamine was a good solvent for the ethynylation reaction of the hindered ketone. Racemic and optically active 17β-hydroxy-13β, 17α-diethylgon-4-en-3-one were synthesized from 1-vinyl-6-methoxy-1-tetralol and 2-ethyl-1,3-cyclopentanedion. The dextrorotatory diethylgonenone as well as the corresponding racemic diethylgonenone showed strong anabolic activities, whereas the levorotatory compound had no biological activity.
- 公益社団法人日本薬学会の論文
- 1965-11-25
著者
関連論文
- Total Synthesis of 13β-Allylgonanes. III
- Total Synthesis of 13β-Allylgonanes. II
- Total Synthesis of 13β-Allylgonanes. I. Synthesis of dl-17α-Ethynyl-17β-hydroxy-13β-allylgon-4-en-3-one
- The Structure of 9,14-Epoxy-8,14-seco Steroids
- Total Synthesis of Estrone via Estriol Dimethyl Ether
- An Improved Synthesis of optically Active Steroids
- New Synthesis of 2-Substituted Cyclopentane-1,3-dione
- Syntheses and Steric Hindrances in 13β-Isopropylgonanes
- An Improved Synthesis of Estrogens.
- Syntheses of 1,3-Cyclopentanediones
- Structures of Cyclopentanepolyones
- Syntheses of Racemic and Optically Active 13β-Ethylgonanes.