Total Synthesis of Estrone via Estriol Dimethyl Ether
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概要
- 論文の詳細を見る
Meerwein-Ponndorf reduction of 3-methoxy-8,14-secoestra-1,3,5 (10), 9,15-pentaene-14,17-dione (III) yielded a mixture of rac-17α- and 17β-hydroxy-3-methoxy-8,14-secoestra-1,3,5 (10), 9,15-pentaen-14-one (XI and XII). Cyclization of 17β-benzoate of XII gave 3,16α-dimethoxy estra-1,3,5 (10), 8,14-pentaen-17β-ol 17-benzoate (XV), which was further transformed to rac-estrone (XXI).
- 社団法人日本薬学会の論文
- 1973-04-25
著者
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平賀 謙太郎
武田薬品工業株式会社中央研究所
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平賀 謙太郎
Chemical Research Laboratories Research & Development Division Takeda Chemical Industries Ltd.
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三木 卓一
武田薬品工業株式会社中央研究所
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三木 卓一
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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朝子 典彦
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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