Synthesis of Cephalosporins with Substituted Thiadiazoles directly attached to the C_3-Position. I. Synthesis of 3-(5-Substituted-1,3,4-thiadiazol-2-yl) ceph-3-em Derivatives
スポンサーリンク
概要
- 論文の詳細を見る
3-(5-Substituted-1,3,4-thiadiazol-2-yl) ceph-3-em derivatives were prepared by oxidative ring closure with 2,3-dichloro-5,6-dicyanobenzoquinone directly or after acetylation of 3-thiocarbonylhydrazones, which were obtained from the reaction of 3-formylceph-3-ems and thiocarbonylhydrazines. The antibacterial activity of 7-thienylacetamido-3-(5-substituted-1,3,4-thiadiazol-2-yl) ceph-3-em derivatives (4) against gram-positive organisms was similar to that of cephalothin (CET), while the activity against gram-negative organisms was superior to that of CET. A similar oxidative ring closure reaction with other thiocarbonylhydrazones is also discussed.
- 公益社団法人日本薬学会の論文
- 1980-07-25
著者
-
三木 卓一
Central Research Division, Takeda Chemical Industries, Ltd.
-
松尾 泰介
Central Research Division, Takeda Chemical Industries, Ltd.
-
菅原 徹
Molecular Chemistry Laboratory, Takeda Chemical Industries Ltd.,
-
三木 卓一
武田薬品工業株式会社中央研究所
-
菅原 徹
Molecular Chemistry Laboratory Takeda Chemical Industries Ltd.
-
菅原 徹
Central Research Division, Takeda Chemical Industries, Ltd.
-
桝屋 浩大
Central Research Division, Takeda Chemical Industries, Ltd
-
桝屋 浩大
Central Research Division Takeda Chemical Ind. Ltd.
-
松尾 泰介
Central Research Division Takeda Chemical Industries Ltd.
関連論文
- Synthetic Studies on Condensed-Azole Derivatives. II. Application of a Computer-Assisted Automated Synthesis Apparatus for the Synthesis of N-Substituted Sulfamoylpropylthioimidazo[1,2-b]pyridazines
- Studies on Antiandrogenic Agents. Synthesis of 16β-Ethyl-19-nortestosterone
- Synthesis of Carumonam (AMA-1080) and a Related Compound Starting from (2R, 3R)-Epoxysuccinic Acid
- Chemical Modification of Sulfazecin. Synthesis of 4-Methoxycarbonyl-2-azetidinone-1-sulfonic Acid Derivatives
- Application of a Unique Automated Synthesis System for Solution-phase Peptide Synthesis
- 17-Deoxysteroid類の合成と抗男性ホルモン作用
- 16β-Ethyl-17β-hydroxyestr-4-en-3-one(Oxendolone)の別途合成
- Synthesis and Antiandrogenic Activity of 16β-Substituted-17β-hydroxysteroids
- A Stereoselective Synthesis and Nuclear Magnetic Resonance Spectral Study of Four Epimeric 17-Hydroxy-16-ethylestranes
- A Phosphorylation of Steroids and a Dienone-Phenol Rearrangement leading to a Secosteroidal Aldehyde Which has a Strong Toxicity
- 全合成法による19-Nortestosterone同族体の合成
- Total Synthesis of 13β-Allylgonanes. III
- Total Synthesis of 13β-Allylgonanes. II
- Total Synthesis of 13β-Allylgonanes. I. Synthesis of dl-17α-Ethynyl-17β-hydroxy-13β-allylgon-4-en-3-one
- A Stereoselective Synthesis of 16β-Substituted-17-oxosteroids
- 16-エチル置換ステロイドの全合成
- The Structure of 9,14-Epoxy-8,14-seco Steroids
- Total Synthesis of Estrone via Estriol Dimethyl Ether
- rac-3-(3-Oxo-17β-hydroxy-13-ethylgon-4-en-17α-yl)-propionic Acid γ-Lactoneの全合成
- An Improved Synthesis of optically Active Steroids
- New Synthesis of 2-Substituted Cyclopentane-1,3-dione
- Syntheses and Steric Hindrances in 13β-Isopropylgonanes
- An Improved Synthesis of Estrogens.
- Intramolecular Reactions of Enaminonitriles. A New Synthesis of β-Aminopyrroles and Related Heterocycles
- Intramolecular Reactions of Enaminonitriles. I. A Novel Synthesis of New β-Aminopyrroles and Related Heterocycles
- Synthesis of Cephalosporins with Substituted Thiadiazoles directly attached to the C_3-Position. I. Synthesis of 3-(5-Substituted-1,3,4-thiadiazol-2-yl) ceph-3-em Derivatives
- Synthesis of 3-Carboxyceph-3-em Compounds and Reactions of Cephalosporin Thiolactones
- Synthesis of Cephalosporins with Substituted Thiadiazoles directly attached to the C_3-Position
- Dimethyl 5-Hydroxy-6-methylcinchomeronateからPyrido [3,4-d]-pyridazineおよびα-Styrylpyridazine誘導体の合成
- Studies on the Diels-Alder Reaction of 4-Carboxymethyl-5-ethoxyoxazole
- Studies on the Diels-Alder Reaction of 5-Ethoxy-4-ethoxycarbonylmethyloxazole
- ビタミンB_6同族体の合成
- Further Studies on the Velocity of Diels-Alder Reaction
- Synthesis and Antibacterial Activity of 3-Acylamino-3-methoxy-2-azetidinone-1-sulfonic Acid Derivatives
- Synthesis and Antibacterial Activity of 3-Acylamino-2-azetidinone-1-sulfonic Acid Derivatives
- A New Synthetic Method of 3-Formylcephalosporins
- Investigation of Rhubarbs. III. New Purgative Constituents, Sennosides E and F
- Investigation of Rhubarbs. II. Isolation of Sennoside E, a New Purgative Compound