Studies on Antiandrogenic Agents. Synthesis of 16β-Ethyl-19-nortestosterone
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概要
- 論文の詳細を見る
The mixture of enol acetates (II and III) of 16-acetyl-estrone-3-methyl ether underwent hydrogenolysis under high pressure (100kg/cm^2) of hydrogen in the presence of Raney Ni to form the 16β-ethyl-17β-ol compound (X) in high yield. The mechanism of hydrogenolysis was discussed. This facile and stereoselective introduction of 16β-ethyl and 17β-hydroxy groups was applied to the synthesis of 16β-ethyl-19-nortestosterone (TSAA-291,XIX), which shows strong antiandrogenic activity.
- 社団法人日本薬学会の論文
- 1975-12-25
著者
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馬渕 宏
Pharamaceutical Research Laboratories Ii Pharmaceutical Research Division Takeda Chemcial Industries
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馬渕 宏
Central Research Division, Takeda Chemical Industries, Ltd.
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吉岡 晃一
Central Research Division, Takeda Chemical Industries, Ltd.
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後藤 義一
Central Research Division, Takeda Chemical Industries, Ltd.
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平賀 謙太郎
Central Research Division, Takeda Chemical Industries, Ltd.
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三木 卓一
Central Research Division, Takeda Chemical Industries, Ltd.
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吉岡 晃一
Central Research Division Takeda Chemical Industries Ltd.
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平賀 謙太郎
武田薬品工業株式会社中央研究所
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後藤 義一
武田薬品工業(株)中央研究所
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三木 卓一
武田薬品工業株式会社中央研究所
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