Syntheses and Steric Hindrances in 13β-Isopropylgonanes
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概要
- 論文の詳細を見る
dl-18,18-Dimethylestradiol 3-methyl ether (XII), dl-18,18-dimethyl-19-nortestosterone (II) and their derivatives were synthesized starting from 1-vinyl-6-methoxy-1-tetralol (III) and 2-isopropyl-1,3-crclopentanedione (IV). The steric effect of the 13-isopropyl group over 17-position was observed in every kind of reactions in this series. Both II and dl-17α-ethyl-18,18-dimethyl-19-nortestosterone (XX) showed almost no anabolic and androgenic activity.
- 社団法人日本薬学会の論文
- 1965-11-25
著者
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平賀 謙太郎
武田薬品工業株式会社中央研究所
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平賀 謙太郎
Chemical Research Laboratories Research & Development Division Takeda Chemical Industries Ltd.
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三木 卓一
武田薬品工業株式会社中央研究所
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三木 卓一
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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朝子 典彦
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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