Synthesis of Carbapenems with a Sulfonyl Group in the C-6 Side-Chain and Their Biological Activity(Organic,Chemical)
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概要
- 論文の詳細を見る
A new type of 5,6-cis-carbapenems (racemic) having a sulfonyl group in the C-6 side-chain were synthesized by employing the synthetic methodology reported in our previous papers, and an alternative stereocontrolled synthesis of these 5,6-cis-carbapenems was achieved starting from 8-oxo-7-azabicyclo[4.2.0]oct-3-ene (14) via an intramolecular aldol condensation as the key step. Chiral 5,6-cis-carbapenems were also synthesized from (1S',6R)-8-oxo-7-azabicyclo[4,2.0]oct-3-ene (29), which was derived from cis-1,2,5,6-tetrahydrophthalic anhydride. The carbapenems thus obtained proved to be highly stable to the mouse kidney homogenate, and most of them showed good antibacterial activity as well as potent β-lactamase inhibitory activity.
- 公益社団法人日本薬学会の論文
- 1987-03-25
著者
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吉岡 晃一
Central Research Division, Takeda Chemical Industries, Ltd.
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吉岡 晃一
Central Research Division Takeda Chemical Industries Ltd.
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吉岡 晃一
Research And Development Division Takeda Chemical Industries Ltd.
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落合 道彦
Central Research Division, Takeda Chemical Industries, Ltd.
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川野 泰彦
Central Research Division, Takeda Chemical Industries, Ltd.
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川野 泰彦
Pharmaceutical Research Division Pharmaceutical Research Laboratories Iii Takeda Chemical Industries
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川野 泰彦
Central Research Division Takeda Chemical Industries Ltd.
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田村 典一
武田薬品工業(株)
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田村 典一
Central Research Division, Takeda Chemical Industries, Ltd.
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夏苅 英昭
Central Research Division, Takeda Chemical Industries, Ltd.
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松下 義弘
Central Research Division, Takeda Chemical Industries, Ltd.
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夏苅 英昭
Pharmaceutical Research Laboratories Ii Pharmaceutical Research Division Takeda Chemical Industries
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落合 道彦
Central Research Division Takeda Chemical Industries Ltd.
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松下 義弘
Pharmaceutical Research Laboratories Iii Pharmaceutical Research Division Takeda Chemical Industries
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