Synthesis of 3-Ureido Derivatives of Coumarin and 2-Quinolone as Potent Acyl-CoA : Cholesterol Acyltransferase Inhibitors
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概要
- 論文の詳細を見る
Novel 3-ureido derivatives of 4-phenylcoumarin and 4-phenyl-2-quinolone were synthesized and evaluated for acyl-CoA : cholesterol acyltransferase (ACAT)-inhibitory activity. These derivatives inhibited rat intestinal ACAT with IC_<50> values at the 10^<-8> to 10^<-9> M level and were found to normalize plasma cholesterol levels in cholesterol-fed rats when administered as dietary admixtures.
- 社団法人日本薬学会の論文
- 1995-04-15
著者
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池田 衡
丸石製薬株式会社中央研究所
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目黒 寛司
浜理薬品工業株式会社
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杉山 泰雄
武田薬品工業株式会社 創薬研究本部
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池田 衡
Pharmaceutical Research Division, Pharmaceutical Research Laboratories II, Takeda Chemical Industrie
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目黒 寛司
Pharmaceutical Research Division, Pharmaceutical Research Laboratories II, Takeda Chemical Industrie
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多和田 紘之
Pharmaceutical Research Laboratories II, Pharmaceutical Research Division, Takeda Chemical Industrie
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夏苅 英昭
Pharmaceutical Research Laboratories II, Pharmaceutical Research Division, Takeda Chemical Industrie
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石川 英一郎
Pharmaceutical Research Laboratories II, Pharmaceutical Research Division, Takeda Chemical Industrie
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杉山 泰雄
Pharmaceutical Research Laboratories II, Pharmaceutical Research Division, Takeda Chemical Industrie
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杉山 泰雄
武田薬品工業
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夏苅 英昭
Pharmaceutical Research Laboratories Ii Pharmaceutical Research Division Takeda Chemical Industries
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多和田 紘之
Pharmaceutical Research Laboratories Ii Pharmaceutical Research Division Takeda Chemical Industries
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石川 英一郎
Pharmaceutical Research Laboratories Ii Pharmaceutical Research Division Takeda Chemical Industries
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夏苅 英昭
Pharmaceutical Research Division Takeda Chemical Industries, Ltd.,
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