Studies on Non-Thiazolidinedione Antidiabetic Agents. 1. Discovery of Novel Oxyiminoacetic Acid Derivatives
スポンサーリンク
概要
- 論文の詳細を見る
A novel series of oxyiminoacetic acid derivatives were synthesized in an effort to develop a potent antidiabetic agent, which does not contain the 2,4-thiazolidinedione moiety. These compounds were evaluated for glucose and lipid lowering effects in genetically obese and diabetic KKA^y mice. Several of the compounds showed strong antidiabetic activity, including functional potency at peroxisome proliferator-activated receptor (PPAR)-γ. acid (25) significantly reduced plasma glucose (33%, p<0.01) and plasma triglycelide levels (43%, p<0.01) even at a dosage of 0.001% in diet. Pharmacokinetic analyses of 25 are also reported.
- 2002-10-01
著者
-
左右田 隆
武田薬品工業株式会社医薬研究本部
-
杉山 泰雄
武田薬品工業株式会社 創薬研究本部
-
SUGIYAMA Yasuo
Takeda Chemical Industries, Ltd., Pharmaceutical Research Division
-
Sugiyama Y
Takeda Chemical Industries Ltd. Pharmaceutical Research Division
-
Sugiyama Y
Pharmaceutical Research Laboratories Ii Pharmaceutical Research Division Takeda Chemical Industries
-
杉山 泰雄
武田薬品工業
-
Sugiyama Yasuo
Takeda Chemical Industries Ltd. Pharmaceutical Research Division
-
Imoto H
Takeda Chemical Ind. Ltd. Osaka Jpn
-
Imoto Hiroshi
Takeda Chemical Industries Ltd. Pharmaceutical Research Division
-
MOMOSE Yu
Takeda Chemical Industries, Ltd. Pharmaceutical Research Division
-
Momose Y
Takeda Chemical Ind. Ltd. Osaka Jpn
-
Momose Yu
Takeda Chemical Industries Ltd. Pharmaceutical Research Division
-
Sohda T
Takeda Chemical Industries Ltd. Pharmaceutical Research Division
-
Kimura H
Nihon Biores. Inc. Gifu Jpn
-
KIMURA Hiroyuki
Takeda Chemical Industries, Ltd., Pharmaceutical Research Division
-
IMAMIYA Eikoh
Takeda Chemical Industries, Ltd., Pharmaceutical Research Division
-
SOHDA Takashi
Takeda Chemical Industries, Ltd., Pharmaceutical Research Division
-
Imoto Hiroshi
Graduate School of Bioscience and Biotechnology, Fukui Prefectural University
-
Imamiya E
Takeda Chemical Industries Ltd. Pharmaceutical Research Division
-
Imoto H
Graduate School Of Bioscience And Biotechnology Fukui Prefectural University
-
Kimura H
Pharmaceutical Res. Div. Takeda Pharmaceutical Co. Ltd.
-
Kimura Hiroyuki
Takeda Chemical Industries Ltd. Pharmaceutical Research Division
関連論文
- インスリン抵抗性改善薬ピオグリタゾンの創製
- Studies on Antidiabetic Agents. VII. : Synthesis and Hypoglycemic Activity of 4-Oxazoleacetic Acid Derivatives
- Studies on Antidiabetic Agents. II. Synthesis of 5-[4-(1-Methylcyclohexylmethoxy)-benzyl] thiazolidine-2,4-dione (ADD-3878) and Its Derivatives
- Studies on Antidiabetic Agents. I. Synthesis of 5-[4-(2-Methyl-2-phenylpropoxy)-benzyl] thiazolidine-2,4-dione (AL-321) and Related Compounds
- 新規抗リウマチ薬TAK-603の骨吸収抑制作用
- ピオグリタゾンのインスリン抵抗性改善作用
- Studies on Antidiabetic Agents. XII. Synthesis and Activity of the Metabolites of (±)-5-[p-[2-(5-Ethyl-2-pyridyl)ethoxy]benzyl]-2,4-thiazolidinedione (Pioglitazone)
- Synthesis of 3-Ureido Derivatives of Coumarin and 2-Quinolone as Potent Acyl-CoA : Cholesterol Acyltransferase Inhibitors
- Studies on Antidiabetic Agents. X. Synthesis and Biological Activities of Pioglitazone and Related Compounds
- Studies on Antidiabetic Agents. IX. : A New Aldose Reductase Inhibitor, AD-5467,and Related 1,4-Benzoxazine and 1,4-Benzothiazine Derivatives : Synthesis and Biological Activity
- Syntheses of(4, 1-Benzoxazepine-3-ylidene)acetic Acid Derivatives and Their Inhibition of Squalene Synthase^
- 骨芽細胞分化促進作用を有する新規3-ベンゾチエピン誘導体TAK-778による in vitro および in vivo の骨形成促進作用
- New 1,4-Dihydropyridine Derivatives with Potent and Long-Lasting Hypotensive Effect
- Studies on Antidiabetic Agents. VI. Asymmetric Transformation of (±)-5-[4-(1-Methylcyclohexylmethoxy) benzyl]-2,4-thiazolidinedione (Ciglitazone) with Optically Active 1-Phenylethylamines
- Studies on Antidiabetic Agents. IV. Synthesis and Activity of the Metabolites of 5-[4-(1-Methylcyclohexylmethoxy) benzyl]-2,4-thiazolidinedione (Ciglitazone)
- Antiulcer Activity of 5-Benzylthiazolidine-2,4-dione Derivatives
- Studies on Antidiabetic Agents. III. 5-Arylthiazolidine-2,4-diones as Potent Aldose Reductase Inhibitors
- インスリン抵抗性改善薬, 塩酸ピオグリタゾン
- Studies on Non-Thiazolidinedione Antidiabetic Agents. 2. Novel Oxyiminoalkanoic Acid Derivatives as Potent Glucose and Lipid Lowering Agents
- Studies on Non-Thiazolidinedione Antidiabetic Agents. 1. Discovery of Novel Oxyiminoacetic Acid Derivatives
- Studies on Non-Thiazolidinedione Antidiabetic Agents. 3. Preparation and Biological Activity of the Metabolites of TAK-559
- Mineral Composition of Clay Fractions and Oxygen Vacancies in Silt-Sized Quartz in Soils on the Ka-Etsu Plateau, Fukui, Central Japan-Possibility of Eolian Dust Brought from Northern Asia as Parent Material of Soils(Soil Genesis, Classification and Survey
- Clay Mineralogy of a Podzol Developed under a Sciadopitys verticillata Forest on Mt. Irazu, Shikoku Mountains, Southwest Japan(Soil Chemistry and Mineralogy)
- A Simple Superovulation Method of A Single Injection of Follicle-Stimulating Hormone Combined with Equine Chorionic Gonadotropin for Superovulation of Suffolk Ewes During the Breeding Season : II. The Ovarian Responses and the Embryo Qualities
- A Simple Superovulation Method of A Single Injection of Follicle-Stimulating Hormone Combined with Equine Chorionic Gonadotropin for Superovulation of Suffolk Ewes During the Breeding Season : I. Effects of Different Treatments on the Endocrine Profiles
- Effect of Combined Vitamin E and Insulin Administration on Renal Damage in Diabetic Rats Fed a High Cholesterol Diet(Pharmacology)
- Combined Effect of Vitamin E and Insulin on Cataracts of Diabetic Rats Fed a High Cholesterol Diet (Pharmacology)
- Studies on Disease-Modifying Antirheumatic Drugs. III. Bone Resorption Inhibitory Effects of Ethyl 4-(3,4-Dimethoxyphenyl)-6,7-dimethoxy-2-(1,2,4-triazol-1-ylmethyl)quinoline-3-carboxylate (TAK-603) and Related Compounds
- Studies on Disease-Modifying Antirheumatic Drugs. IV. Synthesis of Novel Thieno[2,3-b : 5,4-c']dipyridine Derivatives and Their Anti-inflammatory Effect
- Studies on Disease-Modifying Antirheumatic Drugs. II. Synthesis and Activity of the Metabolites of Ethyl 4-(3,4-Dimethoxyphenyl)-6,7-dimethoxy-2-(1,2,4-triazol-1-ylmethyl)quinoline-3-carboxylate (TAK-603)