Studies on Antidiabetic Agents. VI. Asymmetric Transformation of (±)-5-[4-(1-Methylcyclohexylmethoxy) benzyl]-2,4-thiazolidinedione (Ciglitazone) with Optically Active 1-Phenylethylamines
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概要
- 論文の詳細を見る
Optical resolution of a new antidiabetic agent, (±)-5-[4-(1-methylcyclohexylmethoxy) benzyl]-2,4-thiazolidinedione (1,ciglitazone) with (-)-and (+)-1-phenylethylamine (PEA) in ethyl acetate resulted in almost complete asymmetric transformation to give the salts, (-)-1・(-)-PEA and (+)-1・(+)-PEA, respectively, in up to quantitative yields. Optical purities of (-)-and (+)-1 obtained from the salts were determined by nuclear magnetic resonance and their absolute configurations were confirmed chemically. The optical isomers showed essentially the same antidiabetic and hypolipidemic activities.
- 公益社団法人日本薬学会の論文
- 1984-11-25
著者
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水野 克利
Chemistry Research Laboratories Research and Development Division, Takeda Chemical Industries, Ltd.
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川松 豊
Central Research Division, Takeda Chemical Industries, Ltd.,
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水野 克利
Central Research Division, Takeda Chemical Ind., Ltd.,
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水野 克利
Chemistry Research Laboratories Research And Development Division Takeda Chemical Industries Ltd.
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左右田 隆
武田薬品工業株式会社医薬研究本部
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川松 豊
干寿製薬株式会社経営戦略室
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左右田 隆
Central Research Division, Takeda Chemical Industries, Ltd.
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