New 1,4-Dihydropyridine Derivatives with Potent and Long-Lasting Hypotensive Effect
スポンサーリンク
概要
- 論文の詳細を見る
In a search for new 1,4-dihydropyridine derivatives with a long-lasting effect on the cardiovascular system, a series of piperazinylalkyl esters (I) bearing a lipophilic substituent on the 4-nitrogen of the piperazine ring was synthesized and tested for hypotensive effect in spontaneously hypertensive rats (SHR). Compounds I, especially those having a diphenylmethyl moiety on the piperazine ring, showed extremely potent and long-lasting hypotensive properties. Analogues related to I were also prepared, and the structure-activity relationships are discussed.
- 公益社団法人日本薬学会の論文
- 1985-09-25
著者
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川松 豊
Central Research Division, Takeda Chemical Industries, Ltd.,
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目黒 寛司
浜理薬品工業株式会社
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左右田 隆
武田薬品工業株式会社医薬研究本部
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川松 豊
干寿製薬株式会社経営戦略室
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目黒 寛司
Central Research Division, Takeda Chemical Industries, Ltd.,
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左右田 隆
Central Research Division, Takeda Chemical Industries, Ltd.
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相沢 正博
Central Research Division, Takeda Chemical Industries, Ltd.
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永岡 明伸
Central Research Division, Takeda Chemical Industries, Ltd.
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永岡 明伸
Central Research Division Takeda Chemical Industries Ltd.
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相沢 正博
Central Research Division Takeda Chemical Industries Ltd.
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