異項環化合物(第3報)2-Amino-α-phenylbenzylideneaminoacetalの閉環反応
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概要
- 論文の詳細を見る
Derivatives of 2-amino-α-phenylbenzylideneaminoacetal (II) were prepared by an amine exchange reaction of Schiff bases (I) of 2-aminobenzophenone with aminoacetal in the presence of an acid catalyst. Cyclization of II with ethanolic hydrogen chloride under mild conditions gave 2,3-dihydro-2-ethoxy-1H-1,4-benzodiazepine derivatives (III) which were easily hydrolyzed to their corresponding 2-hydroxy-1,4-benzodiazepines (IV). Chromium oxidation of IV afforded the known 1,4-benzodiazepin-2-ones (V). When the cyclization reaction was carried out under reflux conditions, 3-aminoquinoline derivatives (VI and VII) were obtained as a result of an intramolecular rearrangement.
- 公益社団法人日本薬学会の論文
- 1973-10-25
著者
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目黒 寛司
浜理薬品工業株式会社
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桑田 胖
Central Research Division, Takeda Chemical Industries, Ltd.
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目黒 寛司
武田薬品中央研究所, 化学研究所
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桑田 胖
武田薬品中央研究所, 化学研究所
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桑田 胖
Central Research Division Takeda Chemical Industries Ltd.
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