Synthesis and Biological Activities of New 2-Substituted 1,4-Benzoxazine Derivatives
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概要
- 論文の詳細を見る
A series of new 1,4-benzoxazine derivatives (XI, XII) possessing (4-phenyl-1-piperazinyl)alkyl moieties at the 2-position and related compounds (XIII) were synthesized and tested for calcium antagonistic, calmodulin antagonistic and antihypertensive activities. Various compounds had in vitro calmodulin antagonistic activity superior or comparable to that of trifluoperazine. Among these compounds, tetrahydronaphtho[2,3-b][1,4]oxazine derivatives such as 51,53,54,58,59,60,73 and 75 showed potent antihypertensive effects in spontaneously hypertensive rats. Optical isomers of 51 were also synthesized and evaluated biologically. No differences in biological activities were seen between the enantiomers.
- 社団法人日本薬学会の論文
- 1991-11-25
著者
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西川 浩平
日本製薬株式会社研究本部
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西川 浩平
Pharamaceutical Research Laboratories I Pharmaceutical Research Division Takeda Chemical Industries
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梶野 正博
Chemistry Research Laboratories Research And Development Division Takeda Chemical Industries Ltd.
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柴生田 由美子
Biology Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.,
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西川 浩平
Biology Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.,
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目黒 寛司
Chemistry Research Laboratories Research and Development Division, Takeda Chemical Industries, Ltd.
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目黒 寛司
浜理薬品工業株式会社
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柴生田 由美子
Biology Research Laboratories Research And Development Division Takeda Chemical Industries Ltd.
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