Heterocycles. V. Syntheses and Structures of 7-Chloro-2-hydrazino-5-phenyl-3H-1,4-benzodiazepines and Some Isomeric 1,4,5-Benzotriazocines
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概要
- 論文の詳細を見る
2-Hydrazino-1,4-benzodiazepine derivatives, III and X, were synthesized from the corresponding 2-amino derivatives Ia and Ib, respectively. It was found, on the other hand, that the reaction of a 2-chloromethylquinazoline 3-oxide (XIII) with hydrazine did not form X but gave a 2-hydroxyamino-1,4,5-benzotriazocine (XIV), which, after hydrogenation over Raney nickel, afforded its deoxygenated compound (XV). The structures of these diazepines and the isomeric triazocines were determined on the basis of chemical and physico-chemical behavior. Novel tricyclic compounds, s-triazolo [4,3-a] [1,4] benzodiazepines IX and XII were also prepared.
- 公益社団法人日本薬学会の論文
- 1973-11-25
著者
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目黒 寛司
Chemistry Research Laboratories Research and Development Division, Takeda Chemical Industries, Ltd.
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目黒 寛司
浜理薬品工業株式会社
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桑田 胖
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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桑田 胖
Central Research Division, Takeda Chemical Industries, Ltd.
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桑田 胖
Central Research Division Takeda Chemical Industries Ltd.
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