Studies on Antidiabetic Agents. XII. Synthesis and Activity of the Metabolites of (±)-5-[p-[2-(5-Ethyl-2-pyridyl)ethoxy]benzyl]-2,4-thiazolidinedione (Pioglitazone)
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概要
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The metabolites of (±)-5-[p-[2-(5-ethyl-2-pyridyl)ethoxy]benzyl]-2,4-thiazolidinedione (1,pioglitazone), which is a representative insulin-sensitizing agent, were synthesized to confirm their structures and for studies of their pharmacological properties. Of the metabolites identified, a compound hydroxylated at the 2-position of the ethoxy chain (3) and compounds oxygenated at the ethyl side chain attached to the pyridine ring (4,5) were found to be active, although the potency was slightly lower than that of the parent compound.
- 社団法人日本薬学会の論文
- 1995-12-15
著者
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池田 衡
丸石製薬株式会社中央研究所
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目黒 寛司
浜理薬品工業株式会社
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左右田 隆
武田薬品工業株式会社医薬研究本部
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左右田 隆
Pharmaceutical Research Division, Pharmaceutical Research Laboratories II, Takeda Chemical Industrie
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池田 衡
Pharmaceutical Research Division, Pharmaceutical Research Laboratories II, Takeda Chemical Industrie
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目黒 寛司
Pharmaceutical Research Division, Pharmaceutical Research Laboratories II, Takeda Chemical Industrie
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