Drug Permeation Behavior in Chitosan Film Prepared on the Metal Plate Loaded with Electric Charge

概要

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A novel method to prepare chitosan film using a newly developed apparatus was previously reported. An electric charge supplied on the cast plate during preparation of the chitosan film produced a particular fiber arrangement of chitosan macromolecules.In this study, the drug permeation behavior was investigated in the film prepared on the metal plate loaded with electric charge (VF) in comparison with the film prepared without supplying electric charge (NVF). As model penetrants, caffeine, indomethacin and lidocaine were employed as neutral, acidic and alkaline compounds, respectively. The drug permeation through VF was significantly suppressed compared with NVF. The permeation-suppressing effect of VF was considered to be dependent on the large volume of the crystal-part in VF and fiber orientation of chitosan macromolecules in VF. The permeability coefficient for indomethacin was unusually large compared with those for caffeine and lidocaine, suggesting that the accumulation of indomethacin molecules on the surface of the chitosan films, due to an electric attraction between indomethacin and cationized chitosan molecules.
公益社団法人日本薬学会の論文
1997-01-15