Targeting of Soybean-Derived Sterylglucoside Liposomes to Liver Tumors in Rat and Mouse Models
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概要
- 論文の詳細を見る
The blood clearance, tissue uptake and antitumor efficacy against liver metastasis of M5076 reticulosarcoma in mice and against primary liver cancer in rats of doxorubicin (DOX) encapsulated in two types of liposomes, with and without a soybean-derived sterylglucoside mixture (SG), were examined. Liposomes entrapping DOX were composed of dipalmitoylphosphatidylcholine (DPPC), SG and cholesterol (Ch) at a molar ratio of 6 : 1 : 3,(SG-liposomes) and 6 : 0 : 4 (non-SG-liposomes). Pharmacokinetic analysis of drug disposition was based on the area under the curve (AUC) for liposomes up to 24h following i.v. injection. SG-liposomes showed lower DOX concentrations in blood and higher concentrations in liver compared with non-SG-liposomes. The highest AUC of SG-liposomes in tissue was in liver, 2.4 times higher than that of the free drug. The antitumor efficacy of SG-liposomes was compared with that of free DOX and non-SG-liposomes at a dose of 5 mg DOX/kg. SG-liposomes displayed stronger antitumor activity than the free drug and non-SG-liposomes in murine reticulosarcoma M5076 tumor models and primary liver cancer models reflecting accumulation in hepatocytes. The antitumor activity of SG-liposomes in rats with primary liver cancer was significantly higher compared with free DOX and non-SG-liposomes (ILS : 92.7%).
- 公益社団法人日本薬学会の論文
- 1998-07-15
著者
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Takayama Kozo
Department of Pharmaceutics, Hoshi University
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Shimizu Kazuyuki
Department Of Biochemical Engineering & Science Kyushu Institute Of Technology
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Shimizu K
Department Of Pharmaceutics Hoshi University
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Maitani Y
Institute Of Medicinal Chemistry Hoshi University
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Maitani Yoshie
Department Of Pharmaceutics Hoshi University
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斉 憲栄
北京医科大学薬学院
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Nagai T
Department Of Pharmaceutics Hoshi University
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Takayama Kozo
Department Of Pharmaceutics Hoshi University
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Takayama Kozo
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Hoshi University
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NAGAI TSUNEJI
Department of Pharmaceutics, Hoshi University
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Takayama Kozo
Dep. Of Pharmaceutics Hoshi Univ.
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QI Xian-Rong
School of Pharmaceutical Science, Beijing Medical University
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YOSHII Mayumi
Department of Pharmaceutics, Hoshi University
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KAWANO Kumi
Department of Pharmaceutics, Hoshi University
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SHIMIZU Kazuyuki
Faculty of Pharmaceutical Sciences, Hoshi University
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Maitani Yoshie
Faculty Of Pharmaceutical Sciences Hoshi University
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Qi Xian-rong
School Of Pharmaceutical Science Beijing Medical University
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Nagai Tsuneji
Department Of Pharmaceutics Hoshi University
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Shimizu Kazuyuki
Faculty Of Pharmaceutical Sciences Hoshi University
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Shimizu Kazuyuki
Department Of Biochem.engineering And Science Kyushu Institute Of Technology
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Kawano Kumi
Inst. Of Medicinal Chemistry Hoshi Univ.
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Takayama Kozo
Department of Drug Delivery Research, Hoshi University
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Maitani Yoshie
Department of Drug Delivery Research, Hoshi University
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Shimizu Kazuyuki
Department of Applied Chemistry for Resources, Tokyo University of Agriculture and Technology
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Nagai Tsuneji
Department of Drug Delivery Research, Hoshi University
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