An Integrated Metabolic Pathway Analysis Based on Metabolic Signal Flow Diagram and Cellular Energetics for Saccharomyces cerevisiae
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概要
- 論文の詳細を見る
Noting that a metabolic signall flow diagram-based modelling approach developed by Endo and Inoue (Endo and Inoue, 1976) is restricted to a linear system applicable over the range of linearity of interest, we attempted to overcome such a restriction, and developed an integrated modelling approach by incorporating an energetic model into MSFD. The proposed approach was applied to continuous cultivation of Saccharomyces cerevisiae.The problem was formulated in terms of a flow network that has as its objective maximal ATP synthesis. The metabolic conversion coefficients C_<ij> in the metabolic signal flow diagram can be expressed as a function of z, the fraction of the total carbon flux into the Embden-Meyerhof-Parnas pathway. The resulting model equations were used for analysis of the directions of carbon fluxes and the degree of activation of a particular pathway or reaction loop in S. cerevisiae cultivation, in which the physiological state and the changes in fluxes of the main metabolic pathways in the viable cells can be distinguished in terms of the signs of the metabolic coefficients.
- 社団法人日本生物工学会の論文
- 1997-03-25
著者
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Shimizu Kazuyuki
Department Of Biochemical Engineering & Science Kyushu Institute Of Technology
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SHI HUIDONG
Department of Biochemical Engineering and Science, Kyushu Institute of Technology
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Shi H
Kyushu Inst. Technol. Fukuoka Jpn
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Shi Huidong
Department Of Biochemical Engineering And Science Kyushu Institute Of Technology
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Shimizu Kazuyuki
Department Of Biochemical Engineering And Science Kyushu Institute Of Technology
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Shimizu Kazuyuki
Department Of Biochem.engineering And Science Kyushu Institute Of Technology
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Shimizu Kazuyuki
Department of Applied Chemistry for Resources, Tokyo University of Agriculture and Technology
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