Effects of Solvents on Skin Permeation of Formoterol Fumarate(Biopharmacy)
スポンサーリンク
概要
- 論文の詳細を見る
Effects of various chemicals applied as penetration enhancers on the permeation of formoterol fumarate (FF) across excised rat skin were investigated. Remarkable enhancement was noted with terpenes, fatty acid esters, and higher alcohols, whereas no significant influence was observed in the case of lower alcohols, pyrroli-dones, and amines. At high concentration, a cineole/N-methyl-2-pyrrolidone (NMP) mixed solvent system slightly enhanced the skin permeation of FF compared with cineole alone, and a l-menthol/NMP mixed solvent system caused significant further increase. Maximum skin permeation of FF was seen when the ratio of l-menthol/NMP was 60/40 w/w. From the present results, l-menthol/NMP and isopropyl myristate (IPM)/NMP mixed solvent systems can be considered effective for augmenting skin permeation of FF, with potential applications in transdermal delivery of the drug.
- 公益社団法人日本薬学会の論文
- 2006-01-01
著者
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Takayama Kozo
Department of Pharmaceutics, Hoshi University
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Takayama K
Hoshi Univ. Tokyo Jpn
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Takayama Kozo
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Hoshi University
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NAKAMURA Noriko
Research Institute, Ishikawajima-Harima Heavy Industries Co., Ltd.
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Takayama Satoshi
Research Department Saitama Daiichi Pharmaceutical Co. Ltd.
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KAKUBARI Ikuhiro
Research Department, Saitama Daiichi Pharmaceutical Co., Ltd.
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TAKAYASU Toshiyuki
Research Department, Saitama Daiichi Pharmaceutical Co., Ltd.
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YAMAUCHI Hitoshi
Research Department, Saitama Daiichi Pharmaceutical Co., Ltd.
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Yamauchi Hitoshi
Research Department Saitama Daiichi Pharmaceutical Co. Ltd.
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Kakubari Ikuhiro
Research Department Saitama Daiichi Pharmaceutical Co. Ltd.
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Takayasu Toshiyuki
Research Department Saitama Daiichi Pharmaceutical Co. Ltd.
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Nakamura Noriko
Research Department Saitama Daiichi Pharmaceutical Co. Ltd.
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Nakamura Noriko
Research Center Nihon Micro Coating Co. Ltd.
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Takayama Satoshi
Res. Dept. Saitama Daiichi Pharmaceutical Co. Ltd.
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Takayama Kozo
Department of Drug Delivery Research, Hoshi University
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