Evaluation of Skin Barrier Function Using Direct Current I : Effects of Conductivity, Voltage, Distance between Electrodes and Electrode Area
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概要
- 論文の詳細を見る
The objective of this study was to evaluate the reduction in skin barrier function caused by direct current iontophoresis by measuring resistance in the short term. The experiments were carried out using rat abdominal skin in vivo. The resistance was measured every 125 ms and analyzed using a two-compartment model consisting of surface and skin resistance. Moreover, the initial value and the rate constant of each resistance were calculated with the non-linear approximation program. The proposed method could evaluate the reduction in barrier function from the initial value and the rate constant of surface resistance with high sensitivity and accuracy. Using this proposed method, the effects of the conductivity of an adhesive pad, voltage, the distance between electrodes and the area of electrode were examined. The increase in conductivity of the adhesive pad decreased the initial value since the rate constant increased. The reduction in barrier function depends on voltage. Although the barrier function decreased up until an electrode distance of 1 cm, it increased beyond 1 cm. These phenomena contributed to the current pass portion in the skin because the resistance was in the order of the stratum corneum, epidermis and dermis. The initial value decreased with increasing electrode area. However, the rate constant was little affected since the current density of a topical electrode adjacent to the other electrode was high.
- 公益社団法人日本薬学会の論文
- 2002-11-01
著者
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Takayama Kozo
Department of Pharmaceutics, Hoshi University
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Takayama K
Hoshi Univ. Tokyo Jpn
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Takayama Kozo
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Hoshi University
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Takayama Kozo
Dep. Of Pharmaceutics Hoshi Univ.
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KANEBAKO Makoto
Fuji Research Laboratories, Pharmaceutical Division, Kowa Company, LTD.
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INAGI Toshio
Fuji Research Laboratories, Pharmaceutical Division, Kowa Company, LTD.
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Inagi T
Kowa Co. Ltd. Shizuoka Jpn
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Kanebako M
Kowa Co. Ltd. Shizuoka Jpn
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Takayama Kozo
Department of Drug Delivery Research, Hoshi University
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Kanebako Makoto
Fuji Research Laboratories, Pharmaceutical Division, Kowa Co., Ltd.
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Inagi Toshio
Fuji Research Laboratories, Pharmaceutical Division, Kowa Co., Ltd.
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